Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring
| Autor: | Javier T. Granados Riverón, Maryangel Perea-Cabrera, Leonardo J. Mejía-Marín, Begoña Segura-Stanford, Rocío Sánchez-Urbina, Julio R. Erdmenger-Orellana, Alejandra Contreras-Ramos, Evelyn G. Alvarado-Terrones, Arturo Lopez-Yañez Blanco, Miguel Klünder-Klünder, Norma Balderrabano-Saucedo, Elizabeth Hernández-Carbajal, G. Díaz-Rosas |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Heart Defects Congenital Male 0301 basic medicine medicine.medical_specialty Heart disease 030204 cardiovascular system & hematology 030105 genetics & heredity Body Mass Index 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors medicine Humans Obesity Total anomalous pulmonary venous connection Risk factor Mexico Index case Obstetrics business.industry Incidence (epidemiology) Scimitar Syndrome Infant Newborn General Medicine medicine.disease Gestational diabetes Parity Child Preschool Gestation Female business |
| Zdroj: | Archives of Medical Research. 49:109-113 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2018.06.001 |
| Popis: | The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC.55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included. Both groups had no maternal history of addiction, pre-eclampsia, or type 1, 2 or gestational diabetes mellitus. Complete clinical histories were obtained for the women in both groups and perinatal and birth data were recorded. In addition, genealogies across three generations were constructed to determine affected first- or second-degree relatives with complex congenital heart disease.Among the maternal characteristics analyzed, women in group I had a higher number of pregnancies before gestation of the index case (p =0.05), and the Body Mass Index (BMI) before pregnancy was higher compared to Group II (p 0.05), with an adjusted risk of OR = 3.6 (p = 0.011). The family history showed a higher prevalence in the group of patients with TAPVC compared to healthy children (p 0.05).Maternal obesity before pregnancy is a risk factor for the development of CATVP in children in the Mexican population. |
| Databáze: | OpenAIRE |
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