Bioactive Diterpenes from Callicarpa longissima
| Autor: | Tsong-Long Hwang, Ji-Shu Tsai, Yuan-Bin Cheng, Chia-Ching Liaw, Chung-Hsiung Chen, Ya-Ching Shen, Won-Bo Wang, Jih-Hwa Guh, Yuan-Wei Liu |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Stereochemistry Anti-Inflammatory Agents Callicarpa longissima Pharmaceutical Science Callicarpa Crystallography X-Ray Human prostate Analytical Chemistry chemistry.chemical_compound Ursolic acid Drug Discovery Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Chemistry Organic Chemistry Antineoplastic Agents Phytogenic Plant Leaves Complementary and alternative medicine Molecular Medicine Diterpenes Drug Screening Assays Antitumor Cancer cell lines Diterpene |
| Zdroj: | Journal of Natural Products. 75:689-693 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4'-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated. |
| Databáze: | OpenAIRE |
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