Optic nerve head and peripapillary morphometrics in myopic glaucoma
| Autor: | Sieun Lee, Sherry X. Han, Mirza Faisal Beg, Marinko V. Sarunic, Paul J. Mackenzie, Mei Young |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Retinal Ganglion Cells medicine.medical_specialty Intraocular pressure Materials science genetic structures Optic Disk Optic disk Nerve fiber layer Glaucoma Refraction Ocular Severity of Illness Index chemistry.chemical_compound Imaging Three-Dimensional Ophthalmology medicine Myopia Humans Intraocular Pressure Retinal Inner limiting membrane Middle Aged medicine.disease eye diseases medicine.anatomical_structure chemistry Optic nerve sense organs Choroid Tomography Optical Coherence |
| Zdroj: | Investigative ophthalmologyvisual science. 55(7) |
| ISSN: | 1552-5783 |
| Popis: | PURPOSE: To investigate morphological characteristics of optic nerve head and peripapillary region with myopia and glaucoma. METHODS: Ten normal and 17 glaucomatous myopic participants were imaged with a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images were processed and segmented for inner limiting membrane (ILM), posterior border of retinal nerve fiber layer (RNFL), Bruch's membrane (BM), and posterior border of choroid. Seven shape parameters were measured: nerve fiber layer (NFL) thickness; Bruch's membrane opening (BMO) area, eccentricity, and planarity; BMO and BM depths; and choroidal thickness. The results were analyzed by group and regional sector, and multiple regression was performed on each shape parameter with age, axial length, and glaucoma severity, measured by mean deviation (MD). RESULTS: Bruch's membrane opening area (P < 0.001), eccentricity (P = 0.025), and planarity (P = 0.019) were correlated with axial length but not with MD, such that larger, more elliptical, and less planar BMO was associated with longer axial length. Several BMOs displayed a saddle-like shape configuration whose orientation appeared to be aligned with that of the BMO ellipse. All BM showed posterior deformation toward BMO such that BM closer to BMO was more posterior than that farther from BMO. Bruch's membrane depth was correlated with axial length (P = 0.014) and MD (P = 0.040) in intersubject regression, and BMO depth (P = 0.003) and BM depth (P = 0.006) were correlated with MD in intereye regression. Bruch's membrane depth was also associated with age. Choroidal thickness was negatively correlated with age (P = 0.001) and with axial length to a smaller degree (P = 0.034), but not with glaucoma severity. CONCLUSIONS: Axial length was a significant factor in BMO and BM shape in normal and glaucomatous myopic subjects. Posterior deformation of BM was observed in all eyes and significantly associated with functional glaucomatous damage and age. |
| Databáze: | OpenAIRE |
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