Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake
| Autor: | N. E. van‘t Veer, Rogier M. P. H. Crolla, Antonius A.M. Ermens, T. Mulder, M. F. Q. Kluytmans-van den Bergh, Jan Kluytmans, Jannie Romme |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics Administration Oral Gastroenterology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Oral administration Internal medicine Tobramycin Journal Article Medicine Humans Surgical Wound Infection Pharmacology (medical) 030212 general & internal medicine Prospective Studies Antibiotic prophylaxis Prospective cohort study Aged Pharmacology business.industry Colistin 030208 emergency & critical care medicine Antibiotic Prophylaxis Middle Aged Colorectal surgery Anti-Bacterial Agents Infectious Diseases Surgery Female business Colorectal Surgery medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy, 62(1). American Society for Microbiology |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity. |
| Databáze: | OpenAIRE |
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