Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
| Autor: | Marta Bueno, Raquel Corripio, David Torrents-Rodas, Susanna Esteba-Castillo, Laura Blanco-Hinojo, Olga Giménez-Palop, Ester Boixadera-Planas, Joan Deus, Assumpta Caixàs, Jesús Pujol |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty obesity Liquid diet satiety Amylin Article hunger Clusters Internal medicine medicine Pancreatic polypeptide clusters Prader-Willi Síndrome de PYY business.industry Leptin digestive oral and skin physiology nutritional and metabolic diseases General Medicine medicine.disease Obesity Fam Ghrelin nervous system diseases BDNF Endocrinology ghrelin Peptide YY Medicine Obesitat Prader-Willi syndrome business Hormone |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 5170, p 5170 (2021) Repositorio Abierto de la UdL Universitad de Lleida Volume 10 Issue 21 |
| Popis: | Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men age 27.5 ± 8.02 years BMI 32.4 ± 8.14 kg/m2), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 0′, 30′, 60′ and 120′. Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1 that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|