Association between high levels of growth factors in plasma and progression of coronary atherosclerosis
| Autor: | Jan F. Svensson, S. Volk-Jovinge, Christian Landou, Anders Hamsten, U de Faire, Jan-Åke Nilsson |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Intimal hyperplasia Lipoproteins medicine.medical_treatment Myocardial Infarction Radioimmunoassay Coronary Artery Disease Coronary Angiography Platelet Factor 4 Severity of Illness Index Coronary artery disease Internal medicine Internal Medicine medicine Humans Growth Substances Coronary atherosclerosis Retrospective Studies Platelet-Derived Growth Factor Sweden biology medicine.diagnostic_test business.industry Growth factor Middle Aged beta-Thromboglobulin medicine.disease Causality Endocrinology Angiography Linear Models biology.protein Female business Platelet-derived growth factor receptor Platelet factor 4 |
| Zdroj: | Journal of Internal Medicine. 232:397-404 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | Although intimal proliferation of smooth muscle cells (SMC) is recognized as one of the key mechanisms in the development of atherosclerosis, our knowledge of the role of circulating growth factors for SMC in this process is limited. In the present study the plasma levels of platelet-derived growth factor (PDGF), beta-thromboglobulin (beta-TG), platelet factor 4 (PF 4) and total growth factor activity were determined in a group of 30 young postinfarction patients who had participated in an angiographic study of mechanisms associated with progression of coronary atherosclerosis. Significant correlations were found between the total growth factor activity in plasma and progression (r = 0.42, P < 0.05), as well as severity (r = 0.52, P < 0.01), of global coronary atherosclerosis. Attempts to identify the nature of the total growth factor activity indicated that less than 20% could be attributed to PDGF, the major serum mitogen for SMC. PDGF levels determined by radioimmunoassay were not related to progression or severity of global coronary atherosclerosis, but showed a significant association with the number and severity of distinct stenoses (r = 0.40, P < 0.05). Due to the retrospective design of this study, it is not possible to conclude whether there is a causal relationship between circulating growth factors and development of coronary atherosclerosis. |
| Databáze: | OpenAIRE |
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