Ibuprofen slow-release foam dressing reduces wound pain in painful exuding wounds: preliminary findings from an international real-life study
| Autor: | Giulio Maggio, Marco Romanelli, Valentina Dini, Roberto Polignano, Piero Bonadeo |
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| Předmět: |
Male
Vasculitis medicine.medical_specialty International Cooperation Worst Possible Pain Ibuprofen Occlusive Dressings Dermatology Sensitivity and Specificity Severity of Illness Index law.invention Patient satisfaction Randomized controlled trial Reference Values law Skin Ulcer medicine Clinical endpoint Humans Adverse effect Aged Pain Measurement Probability Aged 80 and over Analysis of Variance business.industry Middle Aged Skin ulcer Surgery Occlusive dressing Treatment Outcome Patient Satisfaction Delayed-Action Preparations Anesthesia Wounds and Injuries Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Università di Pisa-IRIS |
| Popis: | Wound pain is a serious problem for people with chronic wounds. The aim of this real-life study was to compare the effect of a foam dressing that releases ibuprofen (Biatain Ibu) with local best practice on the treatment of painful exuding wounds.A total of 185 patients with painful exuding wounds were randomized to either ibuprofen foam treatment (n = 98) or local best practice (n = 87). The primary endpoint was pain relief over 7 days of treatment, assessed daily using a 5-point verbal rating scale (no relief, slight relief, moderate relief, lots of relief, and complete relief). Secondary endpoints included a total reduction in pain intensity for the whole study period (using an 11-point Numeric Box Scale: 0 = no pain to 10 = worst possible pain) and incidence of adverse events (AEs).More patients in the ibuprofen foam treatment group reported wound pain relief and lower wound pain intensity values after 7 days (p0.0001 for both variables). Within the four most common ulcer aetiolgies, patients reported significantly more effective pain relief with ibuprofen foam treatment (venous: p = 0.009, mixed arterial venous: p0.0001, arterial: p = 0.0009, and vasculitis: p = 0.009). In all groups, patients from the ibuprofen foam group reported lower pain intensities. The results were significant for patients with venous (p0.002) and arterial (p0.0001) leg ulcers. Two AEs were reported.The ibuprofen foam represents an effective and safe alternative to local best practice in the management of painful exuding wounds. |
| Databáze: | OpenAIRE |
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