Chemosensory changes and quality of life in patients undergoing hematopoietic stem cell transplantation
| Autor: | Paula Charuhas Macris, Michele E. Lloid, Mark M. Schubert, Susan E. Coldwell, Rania Abasaeed, Sohaib H Soliman |
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| Rok vydání: | 2017 |
| Předmět: |
Olfactory system
Adult Male medicine.medical_specialty Taste medicine.medical_treatment Hematopoietic stem cell transplantation Olfaction Sodium Chloride Decreased taste Article 03 medical and health sciences Olfaction Disorders Taste Disorders 0302 clinical medicine Quality of life Internal medicine medicine Humans In patient 030212 general & internal medicine Aged business.industry Hematopoietic Stem Cell Transplantation Level of functioning Middle Aged Smell Oncology 030220 oncology & carcinogenesis Odorants Sensation Disorders Quality of Life Female business |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 26(10) |
| ISSN: | 1433-7339 |
| Popis: | PURPOSE: to assess magnitude and characteristics of changes in chemosensory function and quality of life (QOL) for patients receiving hematopoietic stem cell transplantation (HSCT). METHODS: Patients (aged 18 years and above) scheduled to undergo HSCT at the Seattle Cancer Care Alliance were tested for chemosensory function at three time points: pre-transplant (Baseline), 30 +/−5 days (Day 30) and 80 +/− 5 days (Day 80) post HSCT. Gustatory function was assessed following procedures developed at the Monell-Jefferson Taste and Smell Clinic. Olfactory testing was conducted using the National Institute of Health Toolbox Odor Identification test. QOL was also assessed. RESULTS: Twenty-nine patients were enrolled in the study between August 2014 and March 2015. Twenty-three patients were included in the analysis, with sixteen tested at all three time points (Baseline, Day 30 and Day 80). The primary finding is decreased taste sensitivity for 0.32 M NaCl, 0.0056 M citric acid and 0.018 M citric acid on Day 30 following HSCT. Increased taste sensitivity for 0.32 M sucrose at Day 30 was also observed. Taste sensitivity largely recovered by Day 80. Olfactory identification scores were unchanged from baseline to Day 30. QOL was reduced at Day 30, but was restored to an acceptable level of functioning and symptoms by Day 80. However, some areas remain impaired. CONCLUSIONS: Alterations in taste perception were confirmed in the early post-transplant period. This was largely resolved within 2.5 months. No obvious impairments were observed in olfactory function. QOL improved by Day 80, though some oral symptoms lingered. |
| Databáze: | OpenAIRE |
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