Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas

Autor: Alessandra Alfieri, Andrea Soricelli, Maurizio Romano, Alfredo Postiglione, Arturo Brunetti, Marco Salvatore, Giorgio Iaconetta, Enrico Tedeschi, Bucciero A
Přispěvatelé: Tedeschi, Enrico, Soricelli, A, Brunetti, Arturo, Romano, M, Bucciero, A, Iaconetta, G, Alfieri, A, Postiglione, A, Salvatore, Marco
Rok vydání: 1996
Předmět:
Male
Time Factors
Image Processing
chemistry.chemical_element
Post injection
Single photon emission
Meningioma
Computer-Assisted
Technetium Tc 99m Exametazime
pathology/radionuclide imaging
Oximes
Image Processing
Computer-Assisted
Meningeal Neoplasms
Thallium-201 imaging
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Prospective Studies
Tomography
Histological examination
Tomography
Emission-Computed
Single-Photon
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Organotechnetium Compounds
General Medicine
Middle Aged
medicine.disease
Thallium Radioisotopes
Single-photon emission tomography
Rapid acquisition
chemistry
Female
Humans
Image Processing
Computer-Assisted
Male
Meningeal Neoplasms
pathology/radionuclide imaging
Meningioma
pathology/radionuclide imaging
Middle Aged
Organotechnetium Compounds
diagnostic use
Oximes
diagnostic use
Prospective Studies
Technetium Tc 99m Exametazime
Thallium Radioisotopes
diagnostic use
Time Factors
Tomography
Emission-Computed
Single-Photon
Thallium
Female
diagnostic use
business
Nuclear medicine
Zdroj: ResearcherID
ISSN: 1619-7089
0340-6997
Popis: To evaluate the possibility of preoperatively obtaining an index of aggressiveness for intracranial meningiomas, we prospectively studied 22 patients with computed tomographic or magnetic resonance imaging evidence of meningeal tumour, using single-photon emission tomography (SPET) of the brain and thallium-201 (201Tl). On a brain-dedicated SPET scanner, a rapid acquisition protocol with early, short scans was started simultaneously with the intravenous administration of 111 MBq 201Tl, covering the initial intratumoral distribution of the tracer. Twenty minutes post injection, a delayed SPET scan was also obtained. On the reconstructed and attenuation-corrected images we calculated the 201Tl concentration in tumour and normal contralateral brain tissue, and compared intratumoral tracer concentration in the initial and the final part of the rapid acquisition protocol. Benign and malignant meningiomas were classified as such based on histological examination. In malignant lesions, the ratio of the 201Tl concentration at 2-4 min post injection to that at 14-16 min was found to be significantly higher than in non-aggressive neoplasms (mean+/-1 SD: 1.14+/-0.31 and 0.56+/-0.13, respectively, P0.01). Conversely, in the delayed scan, most lesions showed high tracer concentration, and the two groups could not be distinguished. In addition, three recurrent meningiomas displayed the same imaging behaviour as the malignant group, i.e. had similar 201Tl concentration values at 2-4 and at 14-16 min. Our findings suggest that the comparative assessment of intratumoral 201Tl concentration at 2-4 and at 14-16 min post injection could provide a fast, simple method to differentiate preoperatively intracranial meningiomas with different biological behaviour.
Databáze: OpenAIRE
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