Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198
| Autor: | Thierry Boon, Am. Knight, Pj. Dyson, Charles De Smet, D. Simonchazottes, Jean-Louis Guénet |
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| Rok vydání: | 1992 |
| Předmět: |
Genetic Linkage
Molecular Sequence Data Immunology Mutant Mice Inbred Strains Biology Polymerase Chain Reaction Genome Mice Gene mapping Antigen Antigens Neoplasm Cricetinae Histocompatibility Antigens Genetics Animals Gene family Gene Chromosome 7 (human) Polymorphism Genetic Base Sequence Chromosome Mapping Chromosome Molecular biology Blotting Southern Polymorphism Restriction Fragment Length |
| Zdroj: | Immunogenetics. 35:316-323 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/bf00189894 |
| Popis: | Tum- comprises a class of genes, mutation of which in P815 tumor cells has led to the acquisition of new cytotoxic T cell-recognized epitopes. The cells carrying the mutant alleles have impaired tumorigenicity compared with their progenitors due to in vivo induction of a cytotoxic T-cell response specific for tum- antigens. Two tum- genes, P91A and P35B, were found to be single copy loci mapping to chromosomes 11 and 15 respectively. A third, P198, was found to map to chromosome 7 and to be a member of a small gene family with other members on chromosomes 13, 14, and 15. Multiple P198-related sequences were found in other mammalian species suggesting the P198 related gene family is a general feature of mammalian genomes. |
| Databáze: | OpenAIRE |
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