Synthesis, characterization & cytocompatibility of poly (diol-co-tricarballylate) based thermally crosslinked elastomers for drug delivery & tissue engineering applications
| Autor: | Somayeh Zamani, Husam M. Younes, Youmna M. Hassouna, Wael Kafienah |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
0206 medical engineering Diol Thermosetting polymer Bioengineering 02 engineering and technology Poly (diol-tricarballylate) Elastomer Biodegradableelastomer Biomaterials Mice chemistry.chemical_compound Drug Delivery Systems Tissue engineering Cell Line Tumor Materials Testing polycyclic compounds Animals Methylene Thermal crosslinking chemistry.chemical_classification Thermalcrosslinking Tissue Engineering technology industry and agriculture Poly(diol-tricarballylate) Polymer Cytocompatibility 021001 nanoscience & nanotechnology 020601 biomedical engineering Polyester Cross-Linking Reagents Elastomers chemistry Chemical engineering Mechanics of Materials Drugdelivery Biodegradable elastomer Drug delivery 0210 nano-technology |
| Zdroj: | Hassouna, Y M, Zamani, S, Kafienah, W & Younes, H M 2018, ' Synthesis, characterization & cytocompatibility of poly (diol-co-tricarballylate) based thermally crosslinked elastomers for drug delivery & tissue engineering applications ', Materials Science and Engineering C, vol. 93, pp. 254-264 . https://doi.org/10.1016/j.msec.2018.07.028 |
| ISSN: | 0928-4931 |
| Popis: | The aim of this study was to investigate the synthesis and in vitro characterization of thermoset biodegradable poly (diol-co-tricarballylate) (PDT) elastomeric polymers for the purpose of their use in implantable drug delivery and tissue engineering applications. The synthesis was based on thermal crosslinking technique via a polycondensation reaction of tricarballylic acid with aliphatic diols of varying chain lengths (C6-C12). PDT prepolymers were synthesized at 140 �C for 20 min. After purification, the prepolymers were molded and kept at 120 �C for 18 h under vacuum to complete the crosslinking process. PDT prepolymers were characterized by DSC, FT-IR, 1H NMR and GPC. The PDT elastomers were also subjected to thermal and structural analysis, as well as sol content, mechanical testing, in vitro degradation and cytocompatibility studies. The mechanical properties and sol content were found to be dependent on synthesis conditions and can be controlled by manipulating the crosslinking density and number of methylene groups in the chain of precursor aliphatic diol. The family of thermally crosslinked PDT biodegradable polyesters were successfully prepared and characterized; besides they have promising use in drug delivery and other biomedical tissue engineering applications. ThisprojectwasmadepossiblebyNPRPgrant#NPRP09-969-3?251fromQatarNationalResearchFund(amemberofQatarFoundation)throughitsNationalPrioritiesResearchProgramgrantedtoDr.H.Younes(LeadPI)andDr.WaelKafienah(PI).Thestatementsmadehereinaresolelytheresponsibilityoftheauthors. Scopus |
| Databáze: | OpenAIRE |
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