In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey
| Autor: | Özcan Deveci, Recep Tekin, Saim Dayan, Alicem Tekin, Tuba Dal, Selahattin Atmaca, Nida Özcan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Turkey Short Communication Staphylococcus vancomycin lcsh:QR1-502 Microbial Sensitivity Tests linezolid medicine.disease_cause Microbiology lcsh:Microbiology Minimum inhibitory concentration chemistry.chemical_compound Sepsis Acetamides Drug Resistance Bacterial polycyclic compounds Humans Medicine methicillin Oxazolidinones Etest business.industry Significant difference Staphylococcal Infections biochemical phenomena metabolism and nutrition Antimicrobial bacterial infections and mycoses In vitro Anti-Bacterial Agents chemistry Linezolid Vancomycin bacteria business medicine.drug |
| Zdroj: | Brazilian Journal of Microbiology, Vol 45, Iss 3, Pp 829-833 (2014) Brazilian Journal of Microbiology, Volume: 45, Issue: 3, Pages: 829-833, Published: SEP 2014 Brazilian Journal of Microbiology Brazilian Journal of Microbiology v.45 n.3 2014 Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
| ISSN: | 1678-4405 |
| Popis: | Staphylococcus species are one of the major causes of bacterial bloodstream infections. Multi-resistant staphylococci infections are major therapeutic problems. This study was aimed to detect methicillin, linezolid and vancomycin susceptibilities of Staphylococcus isolates. A total of 870 Staphylococcus strains isolated from blood cultures of hospitalized patients with BSI. Antimicrobial susceptibilities of methicillin, linezolid and vancomycin were detected according to the Clinical and Laboratory Standards Institute (CLSI). A total of 771 (88.6%) isolates were coagulase-negative staphylococci (CoNS). 700 (80.5%) isolates were methicillin-resistant (MR) and 170 (19.5%) were methicillin-susceptible (MS). All the MS isolates were also susceptible to linezolid. However 15 (1.7%) of MR strains were resistant to linezolid. The minimum inhibitory concentration range for the linezolid-resistant isolates by Etest was 6-32 µg/mL. The difference between linezolid susceptibilities for MS and MR staphylococci was not quite statistically significant (p = 0.052). There was no statistically significant difference between S. aureus and CoNS isolates for linezolid susceptibility. All of the isolates were susceptible to vancomycin. In conclusion, linezolid is currently an efficient option for the treatment of methicillin-resistant staphylococci infections. |
| Databáze: | OpenAIRE |
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