| Autor: |
Fatemeh Maghsoudinia, Hadi Akbari-Zadeh, Fahimeh Aminolroayaei, Fariba Farhadi Birgani, Ahmad Shanei, Roghayeh Kamran Samani |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
European Journal of Pharmaceutical Sciences. 174:106207 |
| ISSN: |
0928-0987 |
| DOI: |
10.1016/j.ejps.2022.106207 |
| Popis: |
Theranostic agents use simultaneous for diagnostic and therapeutic procedures. In the present study, the effect of Gd-DOTA/doxorubicin-loaded perfluorohexane nanodroplets as a theranostic nanoparticle for control released drug delivery and ultrasound/MR imaging was investigated on B16F10 melanoma cancer cells. The intracellular uptake was performed by inductively coupled plasma optical emission spectrometry (ICP-OES) that indicated sonicated Gd-DOTA/DOX@PFH NDs uptake by cancer cells was approximately 1.5 times more than the non-sonicated nanodroplets after 12 h. In vitro and in vivo toxicity assays revealed that synthesized NDs are biocompatible and do not have organ toxicity. Ultrasound exposure significantly enhanced the release of doxorubicin from NDs (P-value 0.05). Ultrasound echogenicity and T |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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