Radiotracers for imaging of Parkinson's disease
| Autor: | Seyed Jalal Hosseinimehr, Nasrin Abbasi Gharibkandi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Diagnostic Imaging
medicine.medical_specialty Parkinson's disease Disease Single-photon emission computed tomography 01 natural sciences Neuroprotection 03 medical and health sciences Dopamine Drug Discovery medicine Humans Positron emission Radioactive Tracers 030304 developmental biology Pharmacology Tomography Emission-Computed Single-Photon 0303 health sciences Radiochemistry medicine.diagnostic_test 010405 organic chemistry Chemistry Organic Chemistry Dopaminergic Parkinson Disease General Medicine medicine.disease 0104 chemical sciences Positron-Emission Tomography Radiology Differential diagnosis medicine.drug |
| Zdroj: | European journal of medicinal chemistry. 166 |
| ISSN: | 1768-3254 |
| Popis: | Radiotracers along with single photon emission computed tomography (SPECT) and positron emission computed tomography (PET) instruments have led to significant advances in the knowledge of the neurobiology and pathophysiology of neurodegenerative diseases such as Parkinson's disease (PD), clinical diagnosis and patient care. Valuable information is available on both pathology and progression of the neurodegenerative disease through human brain imaging. Preliminary data from PET and SPECT studies in early PD suggests that dopamine agonists might have a slight neuroprotective effect. They also might slow down the rate of progression of the disease. This review gives an overview of the recent SPECT and PET imaging radiotracers of the dopaminergic system imaging used in order for differential diagnosis and for the determination of the progression rate of PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect