Development of psychophysiological motoric reactivity is influenced by peripubertal pharmacological inhibition of gonadotropin releasing hormone action — Results of an ovine model

Autor: Jane E. Robinson, Lynne M. Fleming, Hans W. Erhard, Erik Ropstad, Neil P. Evans, Ira Haraldsen
Přispěvatelé: Institute of Biodiversity, Animal Health and comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Modélisation Systémique Appliquée aux Ruminants (MoSAR), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Faculty of Health Sciences, Oslo University College (OUC), Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital [Oslo], AgroParisTech-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
puberty
Hydrocortisone
Litter Size
Endocrinology
Diabetes and Metabolism
Emotions
Gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone
stress
0302 clinical medicine
Endocrinology
Sexual maturity
Sexual Maturation
GnRH agonist
Animal biology
0303 health sciences
[SDV.BA]Life Sciences [q-bio]/Animal biology
Goserelin
GnRH
psychophysiological motoric reactivity
emotional reactivity
sheep
cortisol
Sex specific
Psychiatry and Mental health
Female
Psychology
medicine.drug
Agonist
musculoskeletal diseases
medicine.medical_specialty
medicine.drug_class
education
Motor Activity
03 medical and health sciences
Sex Factors
Internal medicine
Biologie animale
medicine
Animals
Biological Psychiatry
030304 developmental biology
Endocrine and Autonomic Systems
Sexual dimorphism
Implant
Vocalization
Animal
030217 neurology & neurosurgery
Zdroj: Psychoneuroendocrinology 11 (37), 1876-1884. (2012)
Psychoneuroendocrinology
Psychoneuroendocrinology, Elsevier, 2012, 37 (11), pp.1876-1884. ⟨10.1016/j.psyneuen.2012.03.020⟩
ISSN: 0306-4530
Popis: This study reports the effects of peripubertal GnRH receptor inactivation on development of psychophysiological motoric reactivity (PMR; sometimes also called emotional reactivity), plasma cortisol concentrations and the relationship between plasma cortisol and PMR in male and female sheep. The study formed part of a larger trial and utilised 46 same sex twins. One twin remained untreated (control) while the other received a subcutaneous GnRH agonist (GnRHa Goserelin-Acetate) implant every 4th week, beginning at 8 and 28 weeks of age, in males and females, respectively (different, due to sex specific age of puberty). PMR, a measure of an animals' response to social isolation, was measured over a two minute period at 8, 28 and 48 weeks of age, using a three axis accelerometer. During the test period vocalisation rate was recorded. Cortisol was assayed in blood samples collected on a single day when animals were 40 weeks of age. PMR and vocalisation rate were significantly higher in females than males at all ages tested. At 28 weeks of age (20 weeks treatment) PMR was increased in treated males to the level seen in control females, by 48 weeks of age treated males' PMR was significantly less than controls. In females, 20 weeks of GnRHa treatment (28-48 weeks of age) was not associated with differences in PMR. Cortisol concentrations were significantly higher in females than males but were not affected by treatment. Plasma cortisol concentrations were positively correlated with PMR; this relationship being driven by the treated animals in both sexes. The results demonstrate that PMR is sexually dimorphic and cortisol dependent in sheep from at least 8 weeks of age. Importantly, they also demonstrate that long-term treatment of males with a GnRH agonist results in changes in age-dependent development of PMR.
Databáze: OpenAIRE
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