Development of psychophysiological motoric reactivity is influenced by peripubertal pharmacological inhibition of gonadotropin releasing hormone action — Results of an ovine model
Autor: | Jane E. Robinson, Lynne M. Fleming, Hans W. Erhard, Erik Ropstad, Neil P. Evans, Ira Haraldsen |
---|---|
Přispěvatelé: | Institute of Biodiversity, Animal Health and comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Modélisation Systémique Appliquée aux Ruminants (MoSAR), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Faculty of Health Sciences, Oslo University College (OUC), Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital [Oslo], AgroParisTech-Institut National de la Recherche Agronomique (INRA) |
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Male
puberty Hydrocortisone Litter Size Endocrinology Diabetes and Metabolism Emotions Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone stress 0302 clinical medicine Endocrinology Sexual maturity Sexual Maturation GnRH agonist Animal biology 0303 health sciences [SDV.BA]Life Sciences [q-bio]/Animal biology Goserelin GnRH psychophysiological motoric reactivity emotional reactivity sheep cortisol Sex specific Psychiatry and Mental health Female Psychology medicine.drug Agonist musculoskeletal diseases medicine.medical_specialty medicine.drug_class education Motor Activity 03 medical and health sciences Sex Factors Internal medicine Biologie animale medicine Animals Biological Psychiatry 030304 developmental biology Endocrine and Autonomic Systems Sexual dimorphism Implant Vocalization Animal 030217 neurology & neurosurgery |
Zdroj: | Psychoneuroendocrinology 11 (37), 1876-1884. (2012) Psychoneuroendocrinology Psychoneuroendocrinology, Elsevier, 2012, 37 (11), pp.1876-1884. ⟨10.1016/j.psyneuen.2012.03.020⟩ |
ISSN: | 0306-4530 |
Popis: | This study reports the effects of peripubertal GnRH receptor inactivation on development of psychophysiological motoric reactivity (PMR; sometimes also called emotional reactivity), plasma cortisol concentrations and the relationship between plasma cortisol and PMR in male and female sheep. The study formed part of a larger trial and utilised 46 same sex twins. One twin remained untreated (control) while the other received a subcutaneous GnRH agonist (GnRHa Goserelin-Acetate) implant every 4th week, beginning at 8 and 28 weeks of age, in males and females, respectively (different, due to sex specific age of puberty). PMR, a measure of an animals' response to social isolation, was measured over a two minute period at 8, 28 and 48 weeks of age, using a three axis accelerometer. During the test period vocalisation rate was recorded. Cortisol was assayed in blood samples collected on a single day when animals were 40 weeks of age. PMR and vocalisation rate were significantly higher in females than males at all ages tested. At 28 weeks of age (20 weeks treatment) PMR was increased in treated males to the level seen in control females, by 48 weeks of age treated males' PMR was significantly less than controls. In females, 20 weeks of GnRHa treatment (28-48 weeks of age) was not associated with differences in PMR. Cortisol concentrations were significantly higher in females than males but were not affected by treatment. Plasma cortisol concentrations were positively correlated with PMR; this relationship being driven by the treated animals in both sexes. The results demonstrate that PMR is sexually dimorphic and cortisol dependent in sheep from at least 8 weeks of age. Importantly, they also demonstrate that long-term treatment of males with a GnRH agonist results in changes in age-dependent development of PMR. |
Databáze: | OpenAIRE |
Externí odkaz: |