Disturbed Lipids, Lipoproteins and Triglyceride-Rich Lipoproteins as Well as Fasting and Nonfasting Non-High–Density Lipoprotein Cholesterol in Post-Renal Transplant Patients

Autor:	Andrzej Ksiazek, Elżbieta Kimak, Iwona Baranowicz-Gaszczyk, Janusz Solski
Rok vydání:	2007
Předmět:	Adult Male Nephrology medicine.medical_specialty Resuscitation Apolipoprotein B Lipoproteins Urinary system Critical Care and Intensive Care Medicine chemistry.chemical_compound Internal medicine medicine Humans Triglycerides Dyslipidemias Kidney biology Triglyceride business.industry nutritional and metabolic diseases Fasting General Medicine Middle Aged medicine.disease Kidney Transplantation Lipids Cholesterol medicine.anatomical_structure Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) business Dyslipidemia Lipoprotein
Zdroj:	Renal Failure. 29:705-712
ISSN:	1525-6049 0886-022X
DOI:	10.1080/08860220701460111
Popis:	Serum levels of lipids and lipoproteins were determined in 98 post-renal transplant fasting patients, and lipids and non-high density lipoprotein-cholesterol (non-HDL-C) and lipid ratios in the same post-renal transplant non-fasting patients were compared. The reference group was 87 healthy subjects. All patients were divided into two groups: patients with dyslipidemia (n = 69) and patients with normolipidemic (n = 29). The post-renal transplant patients (TX) with dyslipidemia had a significantly increased concentration of triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), non-HDL-C, apoB, and TRL and lipid ratios, and decreased HDL-C level and lipoprotein ratios. The lipids, lipoproteins, and lipoprotein ratios were significantly beneficial in TX patients with normolipidemic than in those with dyslipidemia. However, TRL concentration and lipid ratios were significantly increased and apoAI/apoCIII significantly decreased as compared to the reference group. The TX patients with dyslipidemia showed a significant correlation between TG and apoB:CIII (r = 0.562, p0.001) and apoCIII (r = 0.380, p0.004), but those with normolipidemic showed a significant correlation only between TG and apoCIII (r = 0.564, p0.008). Regression and Bland-Altman analyses showed excellent correlation between fasting and nonfasting non-HDL-C levels (r = 0.987, R(2) + 0.987) in TX patients both with dyslipidemia and normolipidemic. We think the finding that nonfasting labs that are reliable for non-HDL-C as well as total cholesterol is important, as fasting labs are not always available. Disturbances of lipids, lipoproteins, and TRLs depend not only on the kind of treatment, but due to multiple factors can accelerate cardiovascular complications in post-renal transplant patients with dyslipidemia and also with normolipidemic. Further studies concerning this problem should be completed.
Databáze:	OpenAIRE
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