Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats
| Autor: | Kazuhiro Horii, Tomoya Sawamura, Ayaka Onishi, Natsufu Yuki, Kiyotada Naitou, Takahiko Shiina, Yasutake Shimizu |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G1-G8 |
| ISSN: | 1522-1547 0193-1857 |
| Popis: | Our recent studies have shown that noxious stimuli in the colorectum enhance colorectal motility via the brain and spinal defecation centers in male rats. In female rats, however, noxious stimuli have no effect on colorectal motility. The purpose of this study was to determine whether sex hormones are major contributing factors for sex-dependent differences in neural components of the spinal defecation center. Colorectal motility was measured using an in vivo method under ketamine and α-chloralose anesthesia in rats. Capsaicin was administered into the colorectal lumen as noxious stimuli. Orchiectomy in male rats had no effect on the capsaicin-induced response of colorectal motility. However, in ovariectomized female rats, capsaicin administration enhanced colorectal motility, though intact female animals did not show enhanced motility. When estradiol was administered by using a sustained-release preparation in ovariectomized female rats, capsaicin administration did not enhance colorectal motility unless a GABA |
| Databáze: | OpenAIRE |
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