Ovarian Epithelial Dysplasia in Relation to Ovulation Induction and Nulliparity
| Autor: | JC Crow, JJ Nieto, Niculae Constantinovici, CW Perrett, Allan B. MacLean, M Sundaresan, Paul J. Hardiman |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Epithelial dysplasia Ovariectomy medicine.medical_treatment media_common.quotation_subject Ovary Hysterectomy Cohort Studies Ovulation Induction medicine Humans Ovulation Aged Retrospective Studies media_common Ovarian Neoplasms Gynecology business.industry Obstetrics and Gynecology Epithelial Cells Retrospective cohort study Middle Aged medicine.disease Parity medicine.anatomical_structure Oncology Dysplasia Female Ovulation induction Ovarian cancer business Precancerous Conditions |
| Zdroj: | Gynecologic Oncology. 82:344-349 |
| ISSN: | 0090-8258 |
| Popis: | Objective. The goal of this study was to assess the relationship between ovulation induction, nulliparity, and ovarian epithelial dysplasia. Methods. This retrospective cohort study was performed in one teaching and one district general hospital in London. The subjects, 83 women who had undergone hysterectomy and bilateral oophorectomy and whose ovaries were reported as "normal," were divided into three groups: ovulation induction (13), nulliparity (20), and fertile controls (50). These ovaries were independently reviewed by two pathologists who assigned a score of 0, 1, or 2 to nine epithelial cytological and architectural features. The main outcome measure was the total dysplasia score, which was used to quantify the degree of ovarian epithelial abnormality in the three groups. Results. The mean dysplasia score was significantly higher in the women who had undergone ovulation induction than in the fertile controls (7.92 vs 5.70, P = 0.012). The magnitude of the difference between the ovulation induction group and controls remained similar after adjusting for age, parity, and duration of oral contraceptive use (2.17, 95% CI: −0.11–4.44). However, the statistical significance of this difference was reduced ( P = 0.062). We did not find any evidence of a difference in dysplasia score between nulliparous women and controls, neither before ( P = 0.85) nor after adjusting for age and duration of oral contraceptive use ( P = 0.87). Conclusions. These results suggest a possible association between ovarian epithelial dysplasia and ovulation induction therapy, in accord with previous reports of increased risk of ovarian cancer in women with a history of fertility treatment. The higher dysplasia score could be attributable to the drugs used to induce ovulation or to a genetic susceptibility to ovarian cancer. |
| Databáze: | OpenAIRE |
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