Effect of Hepatic Inflammation in Chronic Hepatitis C Infection on Fibrosis Assessment by Arrival Time Parametric Imaging

Autor: Takahide Kudo, Hidenari Nagai, Noritaka Wakui, Yoshinori Igarashi, Yasukiyo Sumino, Mie Shinohara, Michio Kogame, Yasushi Matsukiyo, Takashi Ikehara, Kenichi Maruyama, Koichi Momiyama, Teppei Matsui, Takanori Mukozu, Daigo Matsui, Yasuko Daido, Yu Ogino
Rok vydání: 2018
Předmět:
Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Time Factors
arrival time parametric imaging
Contrast Media
liver circulation
Risk Assessment
Severity of Illness Index
Gastroenterology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Fibrosis
Parametric imaging
Internal medicine
Image Interpretation
Computer-Assisted
Biopsy
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Stage (cooking)
Aged
Retrospective Studies
Original Research
liver fibrosis
Inflammation
Kidney
medicine.diagnostic_test
business.industry
Biopsy
Needle
Ultrasound
Ultrasonography
Doppler
Blood flow
Hepatitis C
Chronic
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
medicine.anatomical_structure
030220 oncology & carcinogenesis
Liver biopsy
Disease Progression
Elasticity Imaging Techniques
Female
030211 gastroenterology & hepatology
hepatitis C
business
Zdroj: Ultrasound Quarterly
ISSN: 1536-0253
0894-8771
DOI: 10.1097/ruq.0000000000000355
Popis: Arrival time parametric imaging (At-PI) in contrast-enhanced ultrasonography is useful for assessing liver fibrosis in chronic hepatitis C (CHC) infection. The study aimed to elucidate the effect of hepatic inflammation on At-PI efficiency. Subjects were 159 CHC patients who underwent contrast-enhanced ultrasonography immediately before liver biopsy. Ultrasound contrast agent was injected, and contrast dynamics of the S5 to S6 region of the liver and right kidney were recorded for 40 seconds. The At-PI of liver parenchyma blood flow was generated using saved video clips. Hepatic blood flow during the first 5 seconds after starting contrast injection was displayed in red and that after another 5 seconds was displayed in yellow. The ratio of red (ROR) in At-PI images of the entire liver was measured with ImageJ. Ratio of red values of livers with different activity grades (0–3) were compared for each fibrosis (F) stage as determined by biopsy. Correlations of ROR with alanine aminotransferase (ALT) levels were analyzed using a linear regression line from the distribution map. Comparison of ROR for different activity grades in each F stage revealed no significant differences. Correlation coefficient R (P value) for ALT and ROR was R = −0.0094 (P = 0.43) at F0 to F1, R = −0.186 (P = 0.21) at F2, R = −0.233 (P = 0.27) at F3, and R = 0.041 (P = 0.89) at F4, with no significant correlation between ALT and ROR in any F stage. Hepatic inflammation in CHC infection does not affect At-PI diagnostic accuracy.
Databáze: OpenAIRE
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