The Immune Epitope Database: How Data Are Entered and Retrieved
| Autor: | Nima Salimi, Randi Vita, Kerrie Vaughan, Bjoern Peters, Alessandro Sette, Ward Fleri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Graft Rejection Primates 0301 basic medicine Databases Factual Immunology Epitopes T-Lymphocyte Information Storage and Retrieval Review Article Computational biology Bioinformatics Major histocompatibility complex Epitope Autoimmune Diseases Mice User-Computer Interface 03 medical and health sciences 0302 clinical medicine Immune system Immune Epitope Database and Analysis Resource Histocompatibility Antigens Research community Hypersensitivity Animals Humans Immunology and Allergy biology Graft rejection Organ Transplantation General Medicine 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Search interface Epitopes B-Lymphocyte lcsh:RC581-607 Protein Binding |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2017 (2017) |
| ISSN: | 2314-7156 2314-8861 |
| DOI: | 10.1155/2017/5974574 |
| Popis: | Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epitope and assay information related to infectious diseases, autoimmune diseases, allergic diseases, and transplant/alloantigens for humans, nonhuman primates, mice, and any other species studied. It contains T cell, B cell, MHC binding, and MHC ligand elution experiments. Its data are curated primarily from the published literature and also include direct submissions from researchers involved in epitope discovery. This article describes the process of capturing data from these sources and how the information is organized in the IEDB data. Different approaches for querying the data are then presented, using the home page search interface and the various specialized search interfaces. Specific examples covering diverse applications of interest are given to highlight the power and functionality of the IEDB. |
| Databáze: | OpenAIRE |
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