Serotonin and the Regulation of Mammalian Circadian Rhythms☆
| Autor: | J. S. Sprouse, P. J. Sollars, G. E. Pickard |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures Suprachiasmatic nucleus Circadian clock Biology Serotonergic Monoamine neurotransmitter Endocrinology nervous system Light effects on circadian rhythm Internal medicine medicine sense organs Serotonin Circadian rhythm Neuroscience hormones hormone substitutes and hormone antagonists Retinohypothalamic tract |
| DOI: | 10.1016/b978-0-12-809324-5.02391-9 |
| Popis: | The hypothalamic suprachiasmatic nucleus (SCN) is a circadian oscillator that functions as a biological clock. SCN circadian activity is modulated by serotonergic input arising from the median raphe nucleus. The effects of this monoamine neurotransmitter in the SCN are mediated via several serotonin receptor subtypes that modify the SCN response to light and/or the phase of the SCN oscillation. Disruptions of circadian rhythms are associated with mood disorders and serotonin has been implicated in their pathophysiology. Pharmacological treatments for affective disorders that produce their effects through the serotonergic system can affect the SCN and the regulation of circadian rhythms. |
| Databáze: | OpenAIRE |
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