Saposin-like proteins in Opisthorchis felineus and related opisthorchids
| Autor: | Daria Pirozhkova, Alexey V. Katokhin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Protein family 030106 microbiology Gene Expression Microbiology Saposins 03 medical and health sciences Cricetinae Gene expression Genetics Animals Opisthorchis felineus RNA Messenger Structural motif Molecular Biology Gene Ecology Evolution Behavior and Systematics Phylogeny Clonorchis sinensis biology Immunogenicity Opisthorchis Reproducibility of Results Exons Helminth Proteins biology.organism_classification Introns Alternative Splicing 030104 developmental biology Infectious Diseases RNA Splice Sites Transcriptome Function (biology) |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 78 |
| ISSN: | 1567-7257 |
| Popis: | Saposin B domain-containing or saposin-like proteins (SAPs, SAPLIPs) have been described as lipid/membrane-binding and often show antibacterial and cytolytic activity. Members of this protein family are present in phylogenetically distant organisms, pointing to their functional importance. Several SAPs are found in trematodes and some of them apparently are related to host-parasite interaction as they show cytolytic activity or immunogenicity. In the present study, we search for SAP genes of Opisthorchis felineus, Clonorchis sinensis and O. viverrini, compare and analyze their structure and expression patterns. We define three orthologous groups of SAPs in opisthorchids and suggest a unique protein motif with unknown function in one group of orthologs. |
| Databáze: | OpenAIRE |
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