Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice
| Autor: | Yoshiko Furukawa, Masahiko Sudo, Kuniaki Sugawara, Satoshi Okuyama, Mitsunari Nakajima, Maho Kotani, Kumi Nakamura, Wakana Shinoka, Atsushi Sawamoto |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Threonine medicine.medical_specialty Citrus Neurogenesis Hippocampus Hyperphosphorylation Inflammation tau Proteins Hippocampal formation medicine.disease_cause Applied Microbiology and Biotechnology Biochemistry Neuroprotection Streptozocin Analytical Chemistry Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Serine Animals Phosphorylation Molecular Biology Chemistry Dentate gyrus Organic Chemistry General Medicine Mice Inbred C57BL 030104 developmental biology Endocrinology Neuroprotective Agents Diabetes Mellitus Type 2 Hyperglycemia Microglia medicine.symptom Powders Plant Structures 030217 neurology & neurosurgery Oxidative stress Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 82(8) |
| ISSN: | 1347-6947 |
| Popis: | We previously reported that the dried peel powder of Citrus kawachiensis exerted anti-inflammatory effects in the brain in several animal models. Hyperglycemia induces inflammation and oxidative stress and causes massive damage in the brain; therefore, we herein examined the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the streptozotocin-induced hyperglycemia mice model and in the type 2 diabetic db/db mice model. The C. kawachiensis administration inhibited microglial activation in the hippocampus in the streptozotocin-injected mice. Moreover, The C. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau at 231 of threonine and 396 of serine in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the db/db mice. It was suggested that the dried peel powder of C. kawachiensis exerts anti-inflammatory and neuroprotective effects in the brain. |
| Databáze: | OpenAIRE |
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