Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles
| Autor: | Weitong Song, Zhaogang Teng, Jiong Shi, Jianfei Sun, Bo Chen, Xiaoli Mai, Gao-Jun Teng, Yewei Zhang, Xiaoyan Xin, Haijian Fan, Ying Chang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Cell Respiration Biophysics Reversion Bioengineering Photodynamic therapy 02 engineering and technology Metastasis Biomaterials 03 medical and health sciences Neoplasms medicine Humans Platelet 030304 developmental biology 0303 health sciences Tumor hypoxia Chemistry 021001 nanoscience & nanotechnology medicine.disease Mitochondria Metformin Photochemotherapy Mechanics of Materials Ceramics and Composites Cancer research Myeloid-derived Suppressor Cell Nanoparticles Tumor Hypoxia Immunogenic cell death 0210 nano-technology medicine.drug |
| Zdroj: | Biomaterials. 232:119699 |
| ISSN: | 0142-9612 |
| Popis: | Here, we developed platelet membranes (PM) as nano-carriers to co-encapsulate metformin (Met) and IR780 (PM-IR780-Met NPs). The resulting nano-carrier ensured a longer circulation lifetime and facilitated the greater accumulation of IR780 and Met in tumors owing to the active adhesion between PM and tumor cells. As a photodynamic therapy (PDT) agent, IR780 could effectively kill the tumor by producing toxic reactive singlet oxygen species (ROS), while the introduction of Met inhibited mitochondrial respiration and reduced tumor oxygen consumption, thereby evoking an oxygen-boosted PDT and propelling the immunogenic cell death (ICD)-based immunogenic pathway. Meanwhile, the reversed tumor hypoxia also impeded the myeloid derived suppressor cell (MDSC)-regulated immunosuppressive pathway. Finally, tremendous T cells were recruited and activated, providing a promising platform to eliminate the primary tumors and synchronously opening a new avenue for the effective ablation of tumor metastasis. |
| Databáze: | OpenAIRE |
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