Chemoradiotherapy versus chemotherapy as adjuvant treatment for localized gastric cancer: a propensity score-matched analysis

Autor: Fernanda Capareli, Gabriel C. B. Pereira, Rossana Verónica Mendoza López, Daniel Girardi, Mariana A.G. de Lima, Paulo M. Hoff, Jorge Sabbaga, Marcelo V. Negrao
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Propensity score
Nausea
medicine.medical_treatment
Kaplan-Meier Estimate
Neutropenia
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Recurrence
Stomach Neoplasms
Internal medicine
Genetics
medicine
Mucositis
Humans
Chemotherapy
030212 general & internal medicine
Adjuvant
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Aged
80 and over
EVENTO ADVERSO A MEDICAMENTO
business.industry
Chemoradiotherapy
Adjuvant
Chemoradiotherapy
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Regimen
Treatment Outcome
Oncology
Tolerability
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Female
medicine.symptom
business
Gastric cancer
Febrile neutropenia
Research Article
Zdroj: BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BMC Cancer
ISSN: 1471-2407
Popis: Background Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. Methods This study included consecutive patients with LGC treated at Instituto do Cancer do Estado de Sao Paulo (ICESP) from 2012 to 2015. CRT was based on the INT-0116 regimen and CT consisted of a platinum and fluoropyrimidine doublet. Treatment choice was based on physician preference. Toxicity was evaluated for every cycle. Overall survival (OS) analysis was performed by Kaplan-Meier. A propensity score-matched analysis was performed to minimize selection bias. Results A total of 309 patients were evaluated, 227 in CRT group and 82 in CT group. The most prevalent grade 3/4 toxicities in CRT and CT groups were: nausea/vomiting (9.25 vs 4.9%), fatigue (9.3% vs 2.4%), mucositis (4.4% vs 1.2%), neutropenia (37.8% vs 20.9%), febrile neutropenia (3.9% vs 0%), anemia (4.3% vs 6.1%), thrombocytopenia (2.6% vs 4.9%), neuropathy (0 vs 2.4%) and hand-foot syndrome (0.4% vs 2.4%). Two grade 5 toxicities (febrile neutropenia and anemia) occurred in CRT group. There was no difference in the pattern of recurrence. After a median follow-up of 23.5 months (CRT) and 20.6 months (CT), there was no difference in OS between groups. Conclusions CT and CRT present similar efficacy and tolerability as adjuvant treatment for LGC.
Databáze: OpenAIRE
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