Aging Men With Insufficient Vitamin D Have a Higher Mortality Risk: No Added Value of its Free Fractions or Active Form
| Autor: | Dirk Vanderschueren, Jos Tournoy, Felipe F. Casanueva, Hannes Moors, Marian Dejaeger, Jolanta Słowikowska-Hilczer, Gianni Forti, Ilpo Huhtaniemi, Giulia Rastrelli, Frederick C. W. Wu, Roger Bouillon, Evelien Gielen, Leen Antonio, Mario Maggi, Terence W O'Neill, Margus Punab |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Survival Status
Adult Male medicine.medical_specialty Vitamin D-binding protein Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Total 25(OH)D Biochemistry Risk Assessment DBP vitamin D deficiency Endocrinology Risk Factors Internal medicine medicine Vitamin D and neurology Humans Prospective Studies Mortality Vitamin D Prospective cohort study Aged business.industry Vitamin D-Binding Protein Biochemistry (medical) Outcome measures Middle Aged medicine.disease Vitamin D Deficiency mortality Ageing 25(OH)2D business free 25(OH)D Follow-Up Studies |
| Popis: | Context Low total 25-hydroxyvitamin D (25(OH)D) has been associated with mortality. Whether vitamin D in its free form or 1,25-dihydroxyvitamin D (1,25(OH)2D), provide any additional information is unclear. Objective To determine what level of 25(OH)D is predictive for mortality and if free 25(OH)D or 1,25(OH) 2 D concentrations have any added value. Methods This prospective cohort comprised 1915 community-dwelling men, aged 40 to 79 years. Intervention included determination of association of total and free 25(OH)D and 1,25(OH) 2 D concentrations with survival status. Vitamin D results were grouped into quintiles. For total 25(OH)D, specific cutoff values were also applied. Cox proportional hazard models were used adjusted for center, body mass index, smoking, alcohol, physical activity, season of blood sample, kidney function, and number of comorbidities. Results A total of 469 (23.5%) men died during a mean follow-up of 12.3 ± 3.4 years. Compared to those with normal vitamin D values (> 30 µg/L), men with a total 25(OH)D of less than 20 µg/L had an increased mortality (hazard ratio [HR] 2.03 [95% CI, 1.39-2.96]; P Conclusion Aging men with vitamin D deficiency have a 2-fold increased mortality risk. Determinations of either the free fractions of vitamin D or measurement of its active form offer no additional information on mortality risks. |
| Databáze: | OpenAIRE |
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