New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma
| Autor: | Se Chan Kang, Hyelin Jeon, Young Ho Song, Ki-Whan Chi, Inhye Kim, Hae Seong Song, Hyunuk Kim, Nem Singh |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Pyruvate dehydrogenase kinase Cell Survival Supramolecular chemistry lcsh:Medicine Antineoplastic Agents Apoptosis Article 03 medical and health sciences 0302 clinical medicine Coordination Complexes Cell Line Tumor Humans lcsh:Science chemistry.chemical_classification Reactive oxygen species Multidisciplinary Liver Neoplasms lcsh:R Fatty acid Biological activity Models Theoretical Rubidium Cell biology Citric acid cycle Crosstalk (biology) 030104 developmental biology chemistry lcsh:Q Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-36755-9 |
| Popis: | We report herein on the design, synthesis and biological activity of Ru-based self-assembled supramolecular bowls as a potent anticancer therapeutic in human hepatocellular cancer. The potent complex induces production of reactive oxygen species (ROS) by higher fatty acid β-oxidation and down-regulation of glucose transporter-mediated pyruvate dehydrogenase kinase 1 via reduced hypoxia-inducible factor 1α. Also, overexpressed acetyl-CoA activates the tricarboxylic acid cycle and the electron transport system and induces hypergeneration of ROS. Finally, ROS overexpressed through this pathway leads to apoptosis. Furthermore, we demonstrate that the naphthalene derived molecular bowl activates classical apoptosis via crosstalk between the extrinsic and intrinsic signal pathway. Our work into the mechanism of Ru-based self-assembled supramolecular bowls can provide valuable insight into the potential for use as a promising anticancer agent. |
| Databáze: | OpenAIRE |
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