Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case-control study

Autor: Kigbafori D. Silué, Nisha Keshary Bhatta, Jürg Utzinger, Joel A. Yao, Harry van Loen, Jan Jacobs, Jarir At Thobari, Moussa Sacko, François Chappuis, Peiling Yap, Yodi Mahendradhata, Rosanna W. Peeling, Jean T. Coulibaly, Pierre H. H. Schneeberger, Ninon S. Horié, Eliézer K. N’Goran, Sakib Burza, Filip Meheus, Mama N. Doumbia, Emmanuel Bottieau, Fransiska Meyanti, Rénion Saye, Narayan Raj Bhattarai, Emilie Alirol, Kristien Verdonck, Basudha Khanal, Raffaella Ravinetto, Lutz von Müller, Pascal Mertens, Mamadou Traoré, Martin W. Bratschi, Céline Schurmans, Suman Rijal, Marleen Boelaert, E. Elsa Herdiana Murhandarwati, Lisette van Lieshout, Aly Landouré, Patrick K. Yao, Sören L. Becker, Katja Polman, Cedric P. Yansouni
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: BMC Infectious Diseases
ISSN: 1471-2334
Popis: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Côte d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.ClinicalTrials.gov; identifier: NCT02105714 .
Databáze: OpenAIRE
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