Association between telomere length and risk of cancer and non-neoplastic diseases: A Mendelian randomization study

Autor: Collaboration, Telomeres Mendelian Randomization, Haycock, P, Burgess, S, Nounu, A, Zheng, J, Okoli, G, Bowden, J, Wade, K, Timpson, N, Evans, D, Willeit, P, Aviv, A, Gaunt, T, Hemani, G, Mangino, M, Ellis, H, Kurian, K, Pooley, K, Eeles, R, Lee, J, Fang, S, Chen, W, Law, M, Bowdler, L, Iles, M, Yang, Q, Worrall, B, Markus, H, Hung, R, Amos, C, Spurdle, A, Thompson, D, O'Mara, T, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N, Lund, E, Duell, E, Canzian, F, Severi, G, Overvad, K, Gunter, M, Tumino, R, Svenson, U, van Rij, A, Baas, A, Bown, M, Samani, N, van t'Hof, F, Tromp, G, Jones, G, Kuivaniemi, H, Elmore, J, Johansson, M, Mckay, J, Scelo, G, Carreras-Torres, R, Gaborieau, V, Brennan, P, Bracci, P, Neale, R, Olson, S, Gallinger, S, Li, D, Petersen, G, Risch, H, Klein, A, Han, J, Abnet, C, Freedman, N, Taylor, P, Maris, J, Aben, K, Kiemeney, L, Vermeulen, S, Wiencke, J, Walsh, K, Wrensch, M, Rice, T, Turnbull, C, Litchfield, K, Paternoster, L, Standl, M, Abecasis, G, SanGiovanni, J, Li, Y, Mijatovic, V, Sapkota, Y, Low, S, Zondervan, K, Montgomery, G, Nyholt, D, van Heel, D, Hunt, K, Arking, D, Ashar, F, Sotoodehnia, N, Woo, D, Rosand, J, Comeau, M, Brown, W, Silverman, E, Hokanson, J, Cho, M, Hui, J, Ferreira, M, Thompson, P, Morrison, A, Felix, J, Smith, N, Christiano, A, Petukhova, L, Betz, R, Fan, X, Zhang, X, Zhu, C, Langefeld, C, Thompson, S, Wang, F, Lin, X, Schwartz, D, Fingerlin, T, Rotter, J, Cotch, M, Jensen, R, Munz, M, Dommisch, H, Schaefer, A, Han, F, Ollila, H, Hillary, R, Albagha, O, Ralston, S, Zeng, C, Zheng, W, Shu, X, Reis, A, Uebe, S, Hüffmeier, U, Kawamura, Y, Otowa, T, Sasaki, T, Hibberd, M, Davila, S, Xie, G, Siminovitch, K, Bei, J, Zeng, Y, Försti, A, Chen, B, Landi, S, Franke, A, Fischer, A, Ellinghaus, D, Flores, C, Noth, I, Ma, S, Foo, J, Liu, J, Kim, J, Cox, D, Delattre, O, Mirabeau, O, Skibola, C, Tang, C, Garcia-Barcelo, M, Chang, K, Su, W, Chang, Y, Martin, N, Gordon, S, Wade, T, Lee, C, Kubo, M, Cha, P, Nakamura, Y, Levy, D, Kimura, M, Hwang, S, Hunt, S, Spector, T, Soranzo, N, Manichaikul, A, Barr, R, Kahali, B, Speliotes, E, Yerges-Armstrong, L, Cheng, C, Jonas, J, Wong, T, Fogh, I, Lin, K, Powell, J, Rice, K, Relton, C, Martin, R, Davey Smith, G
Přispěvatelé: Erasmus MC other, Epidemiology, Pediatrics
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
Cancer Research
Single-nucleotide polymorphism
Genome-wide association study
Disease
Bioinformatics
Polymorphism
Single Nucleotide
Risk Assessment
Article
03 medical and health sciences
Telomere Homeostasis
SDG 3 - Good Health and Well-being
Neoplasms
Mendelian randomization
Journal Article
medicine
Humans
Genetic Predisposition to Disease
Càncer
Germ-Line Mutation
Aged
Cancer
Aged
80 and over
business.industry
Nucleotides
Odds ratio
Mendelian Randomization Analysis
Middle Aged
Telomere
medicine.disease
Nucleòtids
030104 developmental biology
Stem cell division
Oncology
Cardiovascular Diseases
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
Female
ICEP
business
Genome-Wide Association Study
Bristol Population Health Science Institute
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Brennan, P, Paternoster, L, Soranzo, N, Relton, C L, Martin, R M, Davey Smith, G 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945
Dipòsit Digital de la UB
Universidad de Barcelona
Jama Oncology, 3, 636-651
JAMA Oncol. 3, 636-651 (2017)
Jama Oncology, 3, 5, pp. 636-651
Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B M, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Svenson, U, van Rij, A, Baas, A F, Bown, M J, Samani, N J, van t'Hof, F N G & Telomeres Mendelian Randomization Collaboration 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945
Haycock, P C, Burgess, S, Nounu, A, Zheng, J, Okoli, G N, Bowden, J, Wade, K H, Timpson, N J, Evans, D M, Willeit, P, Aviv, A, Gaunt, T R, Hemani, G, Mangino, M, Ellis, H P, Kurian, K M, Pooley, K A, Eeles, R A, Lee, J E, Fang, S, Chen, W V, Law, M H, Bowdler, L M, Iles, M M, Yang, Q, Worrall, B B, Markus, H S, Hung, R J, Amos, C I, Spurdle, A B, Thompson, D J, O'Mara, T A, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, Onland-Moret, N C, Lund, E, Duell, E J, Canzian, F, Severi, G, Overvad, K, Gunter, M J, Tumino, R, Svenson, U, van Rij, A, Baas, A F, Bown, M J & Albagha, O & Ralston, S H 2017, ' Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases : A Mendelian Randomization Study ', JAMA Oncology, vol. 3, no. 5, pp. 636-651 . https://doi.org/10.1001/jamaoncol.2016.5945
JAMA Oncology, 3(5), 636-651. American Medical Association
ISSN: 2374-2437
Popis: Importance The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources Genomewide association studies (GWAS) published up to January 15, 2015. Study Selection GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. Data Extraction and Synthesis Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. Main Outcomes and Measures Odds ratios (ORs) and 95%confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. Results Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95%CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95%CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95%CI, 0.49-0.81]), celiac disease (OR, 0.42 [95%CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95%CI, 0.05-0.15]). Conclusions and Relevance It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
Databáze: OpenAIRE
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