Neuron-specific enolase as a prognostic factor in metastatic malignant melanoma
| Autor: | Elisabeth Paus, Steinar Aamdal, Einar Hannisdal, Einar Wibe |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty Prognostic factor Pathology Large tumour business.industry Melanoma Microgram Enolase medicine.disease Prognosis Gastroenterology Metastasis Metastatic malignant melanoma nervous system Oncology Internal medicine Phosphopyruvate Hydratase medicine Biomarkers Tumor Humans business Pathological |
| Zdroj: | European journal of cancer (Oxford, England : 1990). (10) |
| ISSN: | 0959-8049 |
| Popis: | Serum neuron-specific enolase (NSE) was measured in 63 patients with metastatic malignant melanoma. 20 patients (32%) had elevated serum NSE (> 10 micrograms/l) before the start of treatment. Another 13 patients (21%) developed pathological NSE values during the course of the disease. In many patients, elevated NSE was related to a large tumour burden, and a gradual rise in serum NSE indicated disease progression. Patients with elevated pretreatment NSE had a median survival time of 3 months compared with 12 months for those with normal pretreatment NSE values. NSE thus proved to be a useful prognostic factor in metastatic malignant melanoma. |
| Databáze: | OpenAIRE |
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