Composition of symbiotic bacteria predicts survival in Panamanian golden frogs infected with a lethal fungus
| Autor: | Anna E. Savage, Shawna J. Cikanek, Jenifer B. Walke, Brian Gratwicke, Lisa K. Belden, Celina N. Santiago, Kevin P. C. Minbiole, Reid N. Harris, Nichole M. Mattheus, Matthew H. Becker |
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| Rok vydání: | 2015 |
| Předmět: |
Amphibian
Atelopus Population Molecular Sequence Data General Biochemistry Genetics and Molecular Biology Microbiology Bacterial Proteins biology.animal RNA Ribosomal 16S Animals Chytridiomycosis Microbiome education Symbiosis Research Articles General Environmental Science Chytridiomycota education.field_of_study General Immunology and Microbiology biology Bacteria Host (biology) Microbiota General Medicine Sequence Analysis DNA biology.organism_classification Bufonidae Mycoses General Agricultural and Biological Sciences Symbiotic bacteria |
| Zdroj: | Proceedings. Biological sciences. 282(1805) |
| ISSN: | 1471-2954 |
| Popis: | Symbiotic microbes can dramatically impact host health and fitness, and recent research in a diversity of systems suggests that different symbiont community structures may result in distinct outcomes for the host. In amphibians, some symbiotic skin bacteria produce metabolites that inhibit the growth of Batrachochytrium dendrobatidis (Bd), a cutaneous fungal pathogen that has caused many amphibian population declines and extinctions. Treatment with beneficial bacteria (probiotics) prevents Bd infection in some amphibian species and creates optimism for conservation of species that are highly susceptible to chytridiomycosis, the disease caused by Bd. In a laboratory experiment, we used Bd-inhibitory bacteria from Bd-tolerant Panamanian amphibians in a probiotic development trial with Panamanian golden frogs, Atelopus zeteki , a species currently surviving only in captive assurance colonies. Approximately 30% of infected golden frogs survived Bd exposure by either clearing infection or maintaining low Bd loads, but this was not associated with probiotic treatment. Survival was instead related to initial composition of the skin bacterial community and metabolites present on the skin. These results suggest a strong link between the structure of these symbiotic microbial communities and amphibian host health in the face of Bd exposure and also suggest a new approach for developing amphibian probiotics. |
| Databáze: | OpenAIRE |
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