Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method

Autor: Md. Abdul Aziz, Mahmuda Ferdous, Mohammad Sarowar Uddin, Md. Abdul Barek, Mohammad Safiqul Islam, Khokon Kanti Bhowmik, Md. Shalahuddin Millat, Fahomida Hassan, Md. Shahid Sarwar, Sayma Binte Muhammad
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Interleukin-1beta
Immunology
Uterine Cervical Neoplasms
Malignancy
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
Risk Assessment
Gastroenterology
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Gene Frequency
Predictive Value of Tests
Risk Factors
Internal medicine
Genotype
Genetic model
Biomarkers
Tumor
medicine
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Allele
Gene
Genetic Association Studies
Pharmacology
Cervical cancer
Bangladesh
Interleukin-6
business.industry
Haplotype
Interleukin-4 Receptor alpha Subunit
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
Bonferroni correction
Haplotypes
Case-Control Studies
030220 oncology & carcinogenesis
symbols
Female
business
Zdroj: International Immunopharmacology. 90:107131
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2020.107131
Popis: BACKGROUND Cervical cancer (CC) is the main cause of cancer-related deaths among women in developing countries. It is the second leading female malignancy in Bangladesh in terms of incidence and mortality. Our present study aimed to investigate the association of IL1β (rs16944), IL4R (rs1801275), and IL6 (rs1800797) gene polymorphisms with the susceptibility of cervical cancer. MATERIALS AND METHODS This case-control study was conducted on 252 cervical cancer patients and 228 healthy volunteers, using tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). RESULTS In the case of rs16944 polymorphism, GG genotype (OR = 2.10, 95%CI = 1.24-3.56), dominant model (OR = 1.71, 95% CI = 1.11-2.63), recessive model (OR = 1.54, 95% CI = 1.01-2.35), and G allele (OR = 1.30, 95% CI = 1.005-1.68) were significantly associated with increased cervical cancer risk. Among these, GG genotype and dominant model remained significant after the Bonferroni correction (p
Databáze: OpenAIRE
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