Stability of mismatch negativity event‐related potentials in a multisite study
| Autor: | Margaret A. Niznikiewicz, Jean Addington, Gregory A. Light, Brian J. Roach, Erica Duncan, Jason K. Johannesen, Ming T. Tsuang, Ricardo E. Carrión, Carrie E. Bearden, Tyrone D. Cannon, Barbara A. Cornblatt, Aysenil Belger, Larry J. Seidman, Peter Bachman, Emily M. Owens, Diana O. Perkins, Elaine F. Walker, Daniel H. Mathalon, Kristin S. Cadenhead, Scott W. Woods, Thomas H. McGlashan, Joshua Kenney, Holly K. Hamilton |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Mismatch negativity Audiology Stability (probability) behavioral disciplines and activities 03 medical and health sciences Young Adult 0302 clinical medicine Event-related potential Linear regression medicine Humans Multicenter Studies as Topic Generalizability theory Longitudinal Studies Child generalizability standardization Healthy subjects Negativity effect Electroencephalography Original Articles mismatch negativity (MMN) stability 030227 psychiatry Psychiatry and Mental health Evoked Potentials Auditory Variance components Original Article event‐related potential (ERP) Female Psychology 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | International Journal of Methods in Psychiatric Research |
| ISSN: | 1557-0657 1049-8931 |
| Popis: | Author(s): Roach, Brian J; Hamilton, Holly K; Bachman, Peter; Belger, Aysenil; Carrion, Ricardo E; Duncan, Erica; Johannesen, Jason; Kenney, Joshua G; Light, Gregory; Niznikiewicz, Margaret; Addington, Jean; Bearden, Carrie E; Owens, Emily M; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara A; McGlashan, Thomas H; Perkins, Diana O; Seidman, Larry; Tsuang, Ming; Walker, Elaine F; Woods, Scott W; Mathalon, Daniel H | Abstract: ObjectivesMismatch negativity (MMN), an auditory event-related potential sensitive to deviance detection, is smaller in schizophrenia and psychosis risk. In a multisite study, a regression approach to account for effects of site and age (12-35 years) was evaluated alongside the one-year stability of MMN.MethodsStability of frequency, duration, and frequency + duration (double) deviant MMN was assessed in 167 healthy subjects, tested on two occasions, separated by 52 weeks, at one of eight sites. Linear regression models predicting MMN with age and site were validated and used to derive standardized MMN z-scores. Variance components estimated for MMN amplitude and latency measures were used to calculate Generalizability (G) coefficients within each site to assess MMN stability. Trait-like aspects of MMN were captured by averaging across occasions and correlated with subject traits.ResultsAge and site accounted for less than 7% of MMN variance. G-coefficients calculated at electrode Fz were stable (G = 0.63) across deviants and sites for amplitude measured in a fixed window, but not for latency (G = 0.37). Frequency deviant MMN z-scores averaged across tests negatively correlated with averaged global assessment of functioning.ConclusionMMN amplitude is stable and can be standardized to facilitate longitudinal multisite studies of patients and clinical features. |
| Databáze: | OpenAIRE |
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