Applications of Nanoparticles for Herpes Simplex Virus (HSV) and Human Immunodeficiency Virus (HIV) Treatment
| Autor: | Lebogang Katata-Seru, Steven Mufamadi, Oluwafemi Samuel Obisesan, Hazel Tumelo Mufhandu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Carcinoma Hepatocellular medicine.drug_class media_common.quotation_subject 0206 medical engineering Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering HIV Infections 02 engineering and technology HSL and HSV medicine.disease_cause Pandemic Tumor Microenvironment Potency Medicine Humans Simplexvirus General Materials Science media_common business.industry Therapeutic effect Liver Neoplasms HIV 021001 nanoscience & nanotechnology 020601 biomedical engineering Virology Herpes simplex virus Drug delivery Nanoparticles Antiviral drug 0210 nano-technology business |
| Zdroj: | Journal of biomedical nanotechnology. 17(5) |
| ISSN: | 1550-7033 |
| Popis: | Human Immunodeficiency Virus (HIV) is a global pandemic that has contributed to the burden of disease, and the synergistic interaction between Herpes Simplex Virus (HSV) and HIV has assisted further in the spread of the HIV disease. Moreover, several chemotherapeutic treatment options from antiviral monotherapy to highly active antiretroviral therapy (HAART) have been adopted to manage the infection; however, HIV has developed new mechanisms against these active pharmaceutical agents (APAs), limiting the effect of the drugs. In this article, we reviewed different nanoparticles and their antiviral potency against HSV and HIV infection as well as the effect of drug encapsulated nanoparticles using different drug delivery systems as they palliate to some flaws or deficiencies that the stand-alone drugs present. Drug encapsulated nanoparticles show better treatment outcomes of HSV and HIV infection. The nanoparticles can transverse the anatomic privilege sites to exert their therapeutic effect, and a prolonged and higher dose of the encapsulated therapeutic agent can ease the dosage frequency, thus palliating low drug compliance which the stand-alone drugs fail to perform. Therefore, it is clear that nanoparticles prevent antiviral drug resistance by maintaining sustained drug release over an extended period, improving the therapeutic effect of the entrapped drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|