Wastewater Surveillance of SARS-CoV-2 across 40 U.S. states
| Autor: | Newsha Ghaeli, Mariana Matus, Xiaoqiong Gu, Steven F Rhode, Eric J. Alm, Fuqing Wu, Janelle R. Thompson, Amy Xiao, Katya Moniz, Mary Bushman, William P. Hanage, Katherine H. Huang, Kyle A. McElroy, Katelyn Foppe, Noriko Endo, Wei Lin Lee, Claire Duvallet, Stefan Wuertz, Jianbo Zhang, Peter R. Chai, Timothy B. Erickson, Federica Armas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
Disease surveillance Coronavirus disease 2019 (COVID-19) SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Incidence (epidemiology) Population Outbreak COVID-19 Wastewater Article Disease Outbreaks Environmental health Environmental science Humans RNA Viral Sewage treatment education |
| Zdroj: | medRxiv article-version (status) pre article-version (number) 2 |
| Popis: | Wastewater-based disease surveillance is a promising approach for monitoring community outbreaks. Here we describe a nationwide campaign to monitor SARS-CoV-2 in the wastewater of 159 counties in 40 U.S. states, covering 13% of the U.S. population from February 18 to June 2, 2020. Out of 1,751 total samples analyzed, 846 samples were positive for SARS-CoV-2 RNA, with overall viral concentrations declining from April to May. Wastewater viral titers were consistent with, and appeared to precede, clinical COVID-19 surveillance indicators, including daily new cases. Wastewater surveillance had a high detection rate (>80%) of SARS-CoV-2 when the daily incidence exceeded 13 per 100,000 people. Detection rates were positively associated with wastewater treatment plant catchment size. To our knowledge, this work represents the largest-scale wastewater-based SARS-CoV-2 monitoring campaign to date, encompassing a wide diversity of wastewater treatment facilities and geographic locations. Our findings demonstrate that a national wastewater-based approach to disease surveillance may be feasible and effective. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|