Association between the change in nutritional status in response to tube feeding and the occurrence of infections in children with a solid tumor
| Autor: | W.A. van Staveren, Rob C.A. Sengers, M.A. van 't Hof, R.J.J. Lippens, E. den Broeder, Jules J. M. Tolboom |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Behandelingsresultaten bij kinderen met solide tumoren Physiology Nutritional Status Significant negative correlation Infections Child Nutrition Disorders Cohort Studies Enteral Nutrition Treatment of children with solid tumors Intensive Phase Neoplasms medicine Humans Prospective Studies Solid tumor Child Retrospective Studies Leukopenia business.industry Body Weight Infant Nutritional status Hematology Body Height Cross-Sectional Studies Oncology El Niño Child Preschool Pediatrics Perinatology and Child Health Hospital admission Female medicine.symptom business Weight for height |
| Zdroj: | Pediatric Hematology and Oncology, 17, 7, pp. 567-575 Pediatric Hematology and Oncology, 17, 567-575 |
| ISSN: | 0888-0018 |
| Popis: | In 32 children with a solid tumor, the association between the change in weight for height, in response to 4 weeks of tube feeding during the intensive phase of treatment, and the occurrence of leukopenia, leukopenic infections, and nonleukopenic infections in a period thereafter (4-10 weeks) was studied. Factors possibly influencing the change in weight for height during the first 4 weeks of tube feeding were also assessed. A statistically significant negative correlation (rho = -0.59; p.001) was found between the change in z-score of weight for height in response to the first 4 weeks of tube feeding, and the occurrence of nonleukopenic infections between 4 and 10 weeks. A reduced occurrence of nonleukopenic infections resulted in a significant reduction of the number of days of infection-related hospital admission (rho = .45; p = .009), which, besides providing advantages for the patient, also had economical benefits. The change in weight for height in response to tube feeding was mainly influenced by the incidence of therapy-induced vomiting (r = -.45; p = .02) and by the amount of energy provided by tube feeding (r = .47; p = .007). Based on these findings, it is recommended that naso-gastric tube feeding be used in children with a solid tumor during the early intensive phase of treatment, and that one should aim for a considerable increase in weight for height during the first 4 weeks of administration, since this has been shown to reduce the number of nonleukopenic infections in a subsequent period. The increase in weight for height may be improved by providing an optimal antiemetic protocol, which will increase energy uptake, and an energy-enriched formula, which will increase energy intake. |
| Databáze: | OpenAIRE |
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