ENDOTHELIAL DYSFUNCTION IN CORONARY VESSELS AND THORACIC AORTA OF RATS EXPOSED TO CIGARETTE SMOKE
| Autor: | Eros Antonio de Almeida, Michiko Regina Ozaki, P. A. Ribeiro Jorge |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Physiology Muscle Relaxation Microgram Aorta Thoracic Muscle Smooth Vascular Physiology (medical) Internal medicine medicine.artery medicine Animals Thoracic aorta Rats Wistar Endothelial dysfunction Pharmacology Smoke Aorta Dose-Response Relationship Drug business.industry Smoking medicine.disease Coronary Vessels Acetylcholine Rats Dose–response relationship Cholesterol medicine.anatomical_structure cardiovascular system Cardiology Tobacco Smoke Pollution Endothelium Vascular business medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 22:410-413 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1995.tb02031.x |
| Popis: | 1. The aim of this study was to evaluate the role of endothelium in mediating the response to acetylcholine in the thoracic aorta and coronary vessels of rats exposed to cigarette smoking. Total serum cholesterol was measured at the beginning and end of the experiment. 2. The relaxation response to acetylcholine was significantly impaired in the aortae of rats exposed to cigarette smoking (P < 0.05); and the coronary flow during the administration of acetylcholine (0.02 microgram/min.) was significantly reduced (P < 0.05). The total cholesterol plasma levels increased 31.13% in those exposed to smoke when compared to the controls (P < 0.05). 3. It is concluded that exposure to cigarette smoking increases total serum cholesterol levels, and also produces primary endothelial dysfunction in aorta rings and coronary vessels. |
| Databáze: | OpenAIRE |
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