Nephritic factor (NeF) of alternate pathway (NeFA) and of classical pathway (NeFc)
| Autor: | Jin Seino, Masahiro Arakawa, Kazuo Fukuda, Yasumichi Kinoshita, Takao Saito, Takashi Furuyama |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Alternate pathway Complement Pathway Alternative Sjögren syndrome General Biochemistry Genetics and Molecular Biology Classical complement pathway Glomerulonephritis NEFA Internal medicine medicine Humans Lupus Erythematosus Systemic Complement Pathway Classical Complement Activation Complement C3 Nephritic Factor Complement Inactivator Proteins Plate method biology Chemistry Thyroiditis Autoimmune Autoantibody Complement C4 General Medicine medicine.disease Sjogren's Syndrome Endocrinology Immunology biology.protein Antibody Follow-Up Studies |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 138:401-409 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.138.401 |
| Popis: | ARAKAWA, M., SEINO, J., KINOSHITA, Y., FUKUDA, K., SAITO, T. and FURUYAMA, T. Nephritic Factor (NeF) of Alternate Pathway (NeFA) and of Classical Pathway (NeFc). Tohoku J. exp. Med., 1982, 138 (4), 401-409-NeFA and NeFc were studied in various cases (115 cases). 5 cases were followed up for a long time. NeFA assay was done by the “microtest plate method”. We detected the NeF activity for the first time in the cases of Sjogren syndrome (SjS) and SjS+SLE+Hashimoto's disease (Hashimoto). In some cases NeF activity disappeared after therapy, and in one case NeFA and NeFc were positive at first, but then only NeFA activity became negative following the adequate therapy. As to the antibody nature of NeF, the possibility was suggested that NeFA might be anti C3b autoantibody and NeFc might be anti C4b and/or C4b2a autoantibody. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|