Genetic diversity and transmission networks of HIV-1 strains among men having sex with men (MSM) in Lomé, Togo

Autor: Mounerou Salou, Didier K. Ekouevi, Nicole Vidal, Eric Delaporte, Abla A. Konou, Mireille Prince-David, Anoumou Y. Dagnra, Martine Peeters, Simplice Anato, Assetina Singo-Tokofaï, Palokinam Pitché
Přispěvatelé: Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2016
Předmět:
Adult
Male
0301 basic medicine
Microbiology (medical)
Transmission networks
Population
Human immunodeficiency virus (HIV)
HIV Infections
Biology
medicine.disease_cause
Disease cluster
Microbiology
Genetic diversity
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
immune system diseases
law
Genetics
medicine
Humans
MSM
030212 general & internal medicine
Men having sex with men
Homosexuality
Male
Hiv transmission
education
Molecular Biology
Phylogeny
Ecology
Evolution
Behavior and Systematics
Molecular Epidemiology
education.field_of_study
Phylogenetic tree
Genetic Variation
virus diseases
Virology
3. Good health
030104 developmental biology
Infectious Diseases
Transmission (mechanics)
Togo
HIV-1
Zdroj: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2016, 46, pp.279-285. ⟨10.1016/j.meegid.2016.05.030⟩
ISSN: 1567-1348
1567-7257
DOI: 10.1016/j.meegid.2016.05.030
Popis: International audience; Understanding the HIV epidemic in key populations is important. Today only scarce information is available on HIV-1 strains that circulate in men having sex with men (MSM) in sub-Saharan Africa. Here, we studied for the first time the genetic diversity of HIV-1 strains circulating in the MSM population in Lomé, the capital city from Togo. The overall subtype/CRF distribution in pol (protease and/or partial reverse transcriptase (RT)) among the 79 HIV-1 strains from MSM was as follows: CRF02_AG (72%, n=57), subtype G (2.5%, n=2), sub-subtype A3 (1.3%, n=1), and unique recombinant forms (URF) (24%, n=19). Among the 19 URFs four different mosaic structures were observed, annotated as URF1 to URF4. Fifteen sequences (URF1) had the same mosaic structure in pol (G/CRF02_AG) and could represent a new circulating recombinant form (CRF). Phylogenetic analysis of the RT sequences showed that there were several introductions of CRF02_AG strains in the MSM population, however half of the CRF02_AG and all URF1 strains formed a separate, well-supported cluster suggesting one major introduction of CRF02_AG in the MSM population followed by efficient transmission and emergence of a possible new CRF. At least 40% of the strains fell into recent transmission chains involving two to seven MSM. Comparison with >950 HIV-1 sequences from previous studies in Togo showed intermixing of the HIV-1 epidemics between MSM and the general population. Moreover, an HIV-1 strain from a recently HIV-1 infected male patient from Germany, fell within a cluster of HIV-1 strains from MSM from Togo, illustrating recent exchange between MSM from Africa and people from other geographic regions. With growing evidence of the importance of MSM in the dynamic of the HIV epidemic in Africa there is an urgent need for appropriate interventions to limit HIV transmission in this population group.
Databáze: OpenAIRE
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