β-Adrenergic stimulation induces pro-arrhythmic activity in the caval vein myocardial tissue

Autor: Vladislav S. Kuzmin, A D Ivanova, Leonid V. Rosenshtraukh
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_specialty
Vena Cava
Superior
Epinephrine
Action Potentials
Adrenergic
Stimulation
030204 cardiovascular system & hematology
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
In vivo
Internal medicine
Atrial Fibrillation
Receptors
Adrenergic
beta
Animals
Humans
Medicine
Heart Atria
cardiovascular diseases
Protein kinase A
Vein
Receptor
Membrane potential
030102 biochemistry & molecular biology
General Immunology and Microbiology
business.industry
Myocardium
Atrial fibrillation
General Medicine
Adrenergic beta-Agonists
Atrial Function
medicine.disease
Electrophysiological Phenomena
Rats
medicine.anatomical_structure
cardiovascular system
Cardiology
General Agricultural and Biological Sciences
business
Zdroj: Doklady Biological Sciences. 476:183-187
ISSN: 1608-3105
0012-4966
Popis: Electrical activity of the right superior vena cava (SVC) is considered as a source of the atrial fibrillation. We have shown that bioelectrical properties of the SVC myocardium differ from those of the working atrial myocardium. Electrically evoked action potential duration in SVC is significantly shorter, the resting membrane potential in both stimulated and quiescent SVC preparations is significantly more positive than in atria. Activation of β-adrenoreceptors in SVC myocardium leads to a series of action potentials, and this process depends on protein kinase A. Probably, β-adrenergic stimulation enhances SVC arrhythmogenesis in vivo.
Databáze: OpenAIRE
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