Comparative effects of dietary n-3 docosapentaenoic acid (DPA), DHA and EPA on plasma lipid parameters, oxidative status and fatty acid tissue composition

Autor: Pascale Le Ruyet, Vincent Rioux, Gaëtan Drouin, Etienne Guillocheau, Charlotte Baudry, Philippe Legrand, Pierre Gueret, Daniel Catheline
Přispěvatelé: Laboratoire de Biochimie et Nutrition Humaine, AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), CHU Pontchaillou [Rennes], Groupe Lactalis, Equipe Autre (R&D), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Lactalis Group [R2014-247]
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Docosahexaenoic Acids
Nutritional Supplementation
[SDV]Life Sciences [q-bio]
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
Eicosapentaenoic acid EPA
Rats
Sprague-Dawley
Eating
03 medical and health sciences
chemistry.chemical_compound
Internal medicine
medicine
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Molecular Biology
Triglycerides
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
Cholesterol
Fatty Acids
fungi
Fatty acid
Polyunsaturated fatty acid (PUFA) metabolism
Lipids
Eicosapentaenoic acid
3. Good health
030104 developmental biology
Endocrinology
Eicosapentaenoic Acid
chemistry
Docosahexaenoic acid
Dietary Supplements
Fatty Acids
Unsaturated
lipids (amino acids
peptides
and proteins)
Oxidative status
Docosapentaenoic acid
Docosahexaenoic acid DHA
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Lipoprotein
Polyunsaturated fatty acid
Zdroj: The Journal of Nutritional Biochemistry
The Journal of Nutritional Biochemistry, Elsevier, 2019, 63, pp.186-196. ⟨10.1016/j.jnutbio.2018.09.029⟩
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2018.09.029
Popis: International audience; The specific and shared physiologic and metabolic effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and even more of n-3 docosapentaenoic acid (DPA) are poorly known. We investigated the physiological effects and the overall fatty acid tissue composition of a nutritional supplementation of DPA compared both to EPA and DHA in healthy adult rats. Rats (n=32) were fed with semisynthetic diets supplemented or not with 1% of total lipids as EPA, DPA or DHA in ethyl esters form from weaning for 6 weeks. Fatty acid tissue composition was determined by gas chromatography-mass spectrometry, and blood assays were performed. The DPA supplementation was the only one that led to a decrease in plasma triglycerides, total cholesterol, non-high-density lipoprotein (HDL)-cholesterol, cholesterol esters and total cholesterol/HDL-cholesterol ratio compared to the nonsupplemented control group. The three supplemented groups had increased plasma total antioxidant status and superoxide dismutase activity. In all supplemented groups, the n-3 polyunsaturated fatty acid level increased in all studied tissues (liver, heart, lung, spleen, kidney, red blood cells, splenocytes, peripheral mononucleated cells) except in the brain. We showed that the DPA supplementation affected the overall fatty acid composition and increased DPA, EPA and DHA tissue contents in a similar way than with EPA. However, liver and heart DHA contents increased in DPA-fed rats at the same levels than in DHA-fed rats. Moreover, a large part of DPA seemed to be retroconverted into EPA in the liver (38.5%) and in the kidney (68.6%). In addition, the digestibility of DPA was lower than that of DHA and EPA.
Databáze: OpenAIRE
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