Biventricular tissue tracking demonstrating associations between left ventricular myocardial extracellular volume, pulmonary artery pressure, and reduced right ventricular ejection fraction in patients with systemic lupus erythematosus using cardiovascular MRI
| Autor: | H. Kaddurah, T.T. Han, Ruo-Yang Shi, J.M. Deen, Dong-Aolei An, Bing-Hua Chen, Rui Wu, A. Bacyinski, Jiani Hu, Lian-Ming Wu, Jianrong Xu, Meng Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Hypertension Pulmonary Ventricular Dysfunction Right Contrast Media 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine.artery Image Interpretation Computer-Assisted medicine Humans Lupus Erythematosus Systemic Radiology Nuclear Medicine and imaging Prospective Studies Beta (finance) Lupus erythematosus Ejection fraction medicine.diagnostic_test business.industry Stroke Volume Magnetic resonance imaging General Medicine Stroke volume Prognosis medicine.disease Magnetic Resonance Imaging Pulmonary hypertension Blood pressure Echocardiography Case-Control Studies 030220 oncology & carcinogenesis Pulmonary artery Cardiology Feasibility Studies Female business |
| Zdroj: | Clinical Radiology. 75:237.e17-237.e25 |
| ISSN: | 0009-9260 |
| DOI: | 10.1016/j.crad.2019.09.136 |
| Popis: | AIM To investigate the feasibility and prognostic value of biventricular strain analysis for patients with systemic lupus erythematosus (SLE) and relationship to left ventricular (LV) myocardial fibrosis, pulmonary hypertension (PAH), and right ventricular (RV) ejection fraction (RVEF). MATERIALS AND METHODS A total of 50 SLE patients (47 women; 34.4±12 years) and 15 controls (13 women; 32.9±8.6 years) were imaged via echocardiography and a 3 T magnetic resonance imaging (MRI). Pulmonary artery systolic pressure (sPAP) was assessed using echocardiography. Biventricular global circumferential strain (GCS), global longitudinal strain (GLS), global circumferential strain rate (GCSR), and global longitudinal strain rate (GLSR) as well as LV myocardial extracellular volume (ECV) were derived for each subject. RESULTS Elevated LV ECV was significantly associated with LV GCS (beta –0.428, p=0.000), GLS (beta 0.404, p=0.000), GCSR (beta –0.350, p=0.006), GLSR (beta –0.445, p=0.000) and RV GCS (beta –0.373, p=0.000), and the presence of reduced RVEF was significantly associated with LV GCS (beta –0.338, p=0.002), GLS (beta –0.465, p=0.000) and RV GCS (beta –0.465, p=0.000). Raised sPAP was significantly associated with RV GLS (beta 0.445, p=0.000) and GCSR (beta –0.387, p=0.001). Moreover, there were significantly correlations between LV and RV strain and strain rate. CONCLUSIONS Biventricular strain analysis may be a better prognostic tool for patients with SLE as it allows greater comprehensive analysis and more definitive treatment planning compared to separate assessment of LV or RV contractility. |
| Databáze: | OpenAIRE |
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