Post-Transplantation Natural Killer Cell Count: A Predictor of Acute Graft-Versus-Host Disease and Survival Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Seo Yeon Kim, Hyeon-Seok Eom, Mi-Soon Han, Boram Park, Hyewon Lee, Hyoeun Shim, Sun-Young Kong
Rok vydání: 2016
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Transplantation Conditioning
medicine.medical_treatment
Graft vs Host Disease
Kaplan-Meier Estimate
Hematopoietic stem cell transplantation
Gastroenterology
Immunophenotyping
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
Odds Ratio
Humans
Transplantation
Homologous
Medicine
Clinical significance
Lymphocyte Count
Postoperative Period
Mortality
Proportional Hazards Models
Natural Killer Cell Count
business.industry
Proportional hazards model
Hematopoietic Stem Cell Transplantation
Hematology
Odds ratio
Middle Aged
Prognosis
Lymphocyte Subsets
Killer Cells
Natural
Patient Outcome Assessment
surgical procedures
operative
ROC Curve
Oncology
030220 oncology & carcinogenesis
Immunology
Female
business
Biomarkers
Follow-Up Studies
030215 immunology
Zdroj: Clinical Lymphoma Myeloma and Leukemia. 16:527-535.e2
ISSN: 2152-2650
DOI: 10.1016/j.clml.2016.06.013
Popis: Background Reconstitution of the immune system after allogeneic hematopoietic stem cell transplantation (allo-HSCT) plays an important role in post-transplant outcomes. However, the clinical relevance of the lymphocyte subset (LST) counts to transplant-related complications and survival outcomes after allo-HSCT has not been fully elucidated. Patients and Methods A total of 70 patients who had undergone allo-HSCT from 2007 to 2013, with LST results both 7 days before conditioning and 30 or 90 days after allo-HSCT were included. The LST counts in the peripheral blood were determined using 6-color flow cytometry. Clinical information, including transplant-related events during the first 100 days after allo-HSCT, was reviewed, and any association between these events and LST was analyzed. Results At 30 days after allo-HSCT, the CD4 + T-cell ( P = .009) and B-cell ( P = .035) counts were lower and the natural killer (NK) cell count was greater ( P + T-cell ( P = .001) and NK cell ( P P = .043 and P = .028, respectively) and greater nonrelapse mortality ( P = .036 and P = .033, respectively). A low NK cell count on day 30 was still prognostic for overall survival ( P = .039) on multivariable analysis. Conclusion NK cell counts after allo-HSCT, especially on day 30, were predictive of acute graft-versus-host disease, nonrelapse mortality, and survival. Serial lymphocyte subset analysis can be used to identify and treat patients at risk during the early period after allo-HSCT.
Databáze: OpenAIRE
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