Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus
| Autor: | Ornela Kullolli, Roberta Biagiotti, Letizia Lombardelli, D Tesi, Federica Logiodice, Maria Grazia Giudizi, Enrico Maggi, Giuseppe Ficarra, Sergio Romagnani, Mp Piccinni |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biology medicine.disease_cause Autoimmunity Pathogenesis Th2 Cells stomatognathic system RAR-related orphan receptor gamma medicine Humans General Dentistry Aged Aged 80 and over GATA3 FOXP3 Middle Aged medicine.disease stomatognathic diseases Otorhinolaryngology PPIB Reticular connective tissue Immunology Cytokines Th17 Cells Oral lichen planus Female Lichen Planus Oral |
| Zdroj: | Oral diseases. 20(2) |
| ISSN: | 1601-0825 |
| Popis: | OBJECTIVES: The role of Th17 cells and associated cytokines was investigated in oral lichen planus. MATERIAL AND METHODS: 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1b, RANTES, IL-4, IL-12B, IL-8, IFN-c, TNF-a, IL-1a, IL-18, TGF-b1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. RESULTS: Results showed that Th17-type and Th0-type molecules’ mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules’ mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. CONCLUSIONS: Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. Oral Diseases (2014) 20, 212–218 |
| Databáze: | OpenAIRE |
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