Determining the efficacy of corneal crosslinking in progressive keratoconus
| Autor: | Sidra Malik, Shahzad Nayyar, Mazhar Ishaq, Sadia Humayun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Keratoconus medicine.medical_specialty Efficacy genetic structures Untreated group law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Ophthalmology medicine In patient Dioptre medicine.diagnostic_test business.industry Corneal Crosslinking Mean age General Medicine Corneal topography medicine.disease eye diseases 030104 developmental biology 030221 ophthalmology & optometry Original Article sense organs business Progressive disease |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| DOI: | 10.12669/pjms.332.11690 |
| Popis: | Objective: To determine the Efficacy of Corneal Crosslinkage (CXL), using Corneal Topography, in eyes with progressive Keratoconus. Methods: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from October 2013 to April 2014. A total of 60 eyes of 30 patients were included who presented with bilateral progressive Keratoconus. Each eye of the patient was randomized either to a treatment group (Group-A) or control untreated group (Group-B) of 30 eyes each. A written informed consent was obtained from each patient, following which corneal crosslinkage (CXL) with topical riboflavin eye drops was performed. Follow up visit was done at three months post operatively, Corneal topography was repeated and recorded. Results: The mean age of the patients was 23.13±7.62 years (range 13 to 39 years). There were 26 males and 34 females patients. The mean simK value at the start of study was 50.94±4.84 diopters in Group-A and 49.73±5.24 diopters in Group-B. At three months follow-up, the mean simK value was significantly lower in Group-A (48.28±4.47) as compared to Group-B (51.11±4.85). Keratoconus improved/ remained stable in 34 (56.7%) eyes while progressive disease was noted in 26 (43.3%) eyes. When compared between the groups, the frequency of efficacy was significantly higher in Group-A (86.7% vs. 26.7%; p=.000) as compared to Group-B. Conclusion: Corneal Crosslinking was found effective in causing regression or halting the progression of disease in patients with progressive Keratoconus at three months follow-up, however, the efficacy of corneal crosslinking was unaffected by patient’s age and gender. |
| Databáze: | OpenAIRE |
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