Cytochalasins from endophytic Diaporthe sp. GDG-118
| Autor: | Yan Liang, Jun Li, Xishan Huang, Yu-Yue Qin, Fei Cao, Zhao-Long Xu, Dexiong Zhou, Tu-Xiang Mo, Ruiyun Yang, Xiao-Bo Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Range (biology) fungi Organic Chemistry Sophora tonkinensis food and beverages Plant Science Biology biology.organism_classification 01 natural sciences Biochemistry Plant use of endophytic fungi in defense 0104 chemical sciences Analytical Chemistry Diaporthe sp 010404 medicinal & biomolecular chemistry Botany |
| Zdroj: | Natural Product Research. 35:3396-3403 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | The plant Sophora tonkinensis, possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus Diaporthe sp. GDG-118 was fermented and extracted with methanol. The extract was screened by antifungal and antibacterial assays leading to the discovery of two new 21-acetoxycytochalasins (1���2) and five known cytochalasins (3���7). These two new compounds were elucidated by spectroscopic analyses, and further their absolute configurations were determined by the X-ray of compound 3 and comparing their experimental CD spectra. The antibacterial and antifungal effects of these compounds were evaluated. Compound 2 showed significant inhibitory activity against Bacillus anthraci and Escherichia coli with MIC value of 12.5 ��g/mL, and 7 showed strong antifungal activity against Alternaria oleracea, Pestalotiopsis theae and Colletotrichum capsici with MIC values of 3.125, 1.56 and 1.56 ��g/mL, respectively. |
| Databáze: | OpenAIRE |
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