Role of coxsackievirus and adenovirus receptor (CAR) expression and viral load of adenovirus and enterovirus in patients with dilated cardiomyopathy
| Autor: | Mirnalini Sharma, Kewal K. Talwar, Baijayantimala Mishra, Radha Kanta Ratho, Uma Nahar Saikia, Ajay Bahl |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male 0301 basic medicine Virus genetics Viral Myocarditis Adenoviridae Infections viruses Cardiomyopathy 030204 cardiovascular system & hematology Biology Coxsackievirus medicine.disease_cause Virus Adenoviridae Young Adult 03 medical and health sciences 0302 clinical medicine Virology Enterovirus Infections medicine Humans Prospective Studies cardiovascular diseases Aged Enterovirus Aged 80 and over General Medicine Middle Aged Viral Load biology.organism_classification medicine.disease 030104 developmental biology Immunology cardiovascular system Receptors Virus Female Viral load |
| Zdroj: | Archives of Virology. 161:87-94 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Enteroviruses (EVs) and adenoviruses (AdVs) are two important etiological agents of viral myocarditis and dilated cardiomyopathy (DCM). Both these viruses share a common receptor, the coxsackievirus and adenovirus receptor (CAR), for their infection. However, the role of viral load and CAR expression in disease severity has not yet been completely elucidated. The present study aimed to determine viral load of EV and AdV in DCM patients and correlate them with the level of CAR expression in these patients. Sixty-three DCM cases and 30 controls, each of whom died of heart disease other than DCM and non-cardiac disease respectively, were included. Viral load was determined by TaqMan real-time PCR using primers and probes specific for the AdV hexon gene and the 5'UTR region of EV. The CAR mRNA level was semi-quantitated by RT-PCR, and antigen expression was studied by immunohistochemistry. A significantly high AdV load (p |
| Databáze: | OpenAIRE |
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