Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease
| Autor: | Klas Sjöberg, Hakon Leffler, Pål Stenberg, Birgitta Tenngart, Sten Eriksson, E. Bodil Roth |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Tissue transglutaminase Immunology Cross Reactions medicine.disease_cause Inflammatory bowel disease Coeliac disease Autoimmunity Crohn Disease Antibody Specificity GTP-Binding Proteins Immunopathology medicine Immunology and Allergy Humans Protein Glutamine gamma Glutamyltransferase 2 Aged Autoantibodies Aged 80 and over Transglutaminases biology Factor XIII business.industry Autoantibody Middle Aged medicine.disease Ulcerative colitis Immunoglobulin A Celiac Disease Case-Control Studies Immunoglobulin G biology.protein Colitis Ulcerative Female business medicine.drug |
| Zdroj: | Autoimmunity. 35(5) |
| ISSN: | 0891-6934 |
| Popis: | Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may-when present-be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease. |
| Databáze: | OpenAIRE |
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