The Value of Pretreatment Clinical and Biochemical Parameters in Staging and Prognostic Stratification of Patients with Newly Diagnosed Prostate Carcinoma
| Autor: | Marcel P. M. Stokkel, Van Eck-Smit Bl, Zwartendijk J, Aeilko H. Zwinderman, Ernest K. J. Pauwels |
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| Rok vydání: | 1998 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Pathology Clinical Biochemistry Urology Scintigraphy Bone and Bones Pathology and Forensic Medicine 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate medicine Carcinoma Humans Radionuclide Imaging Aged Neoplasm Staging Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Prostatic Neoplasms Retrospective cohort study Middle Aged Prostate-Specific Antigen Alkaline Phosphatase Prognosis medicine.disease Prostate-specific antigen 030104 developmental biology medicine.anatomical_structure Oncology Bone scintigraphy 030220 oncology & carcinogenesis Alkaline phosphatase business Biomarkers |
| Zdroj: | The International Journal of Biological Markers. 13:70-76 |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460089801300202 |
| Popis: | PurposeTo determine whether it is possible to select patients in whom and for what reason bone scintigraphy should be performed or not, a retrospective study was performed of 161 consecutive patients with newly diagnosed prostate cancer.Materials and methodsFollow-up varied from 1 to 88 months during which 67 patients died. Bone scans were classified from 0 (= normal) to 3 (typical pattern of metastases) and were correlated with age, alkaline phosphatase (AP), prostate specific antigen (PSA), tumor grade, TNM-stage and survival. For survival, 68 patients who were not referred for bone scintigraphy were also evaluated.ResultsAll parameters demonstrated a correlation with the incidence of a positive bone scan, but PSA was the best overall predictor in this (p 1000 ng/ml and patients with PSA values between 20 and 1000 ng/ml in combination with AP >90 U/L (n=24) had bone metastases. Furthermore, a class 3 bone scan was found to be the most important parameter in assessing prognosis and survival (pConclusionsFor staging and prognostic stratification purposes, bone scintigraphy and additional roentgenograms are of value in a selected group of patients. In contrast with a typical pattern of metastases on bone scintigraphy, an abnormal scan (class 1 and 2) at the time of diagnosis is not a poor prognostic parameter of the risk of death. Bone scintigraphy can be omitted in patients with PSA values < 20 ng/ml. In patients with PSA levels > 1000 ng/ml or less increased levels combined with alkaline phosphatase levels > 90 U/L, bone scintigraphy seems to be of no value in staging disease. |
| Databáze: | OpenAIRE |
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