Correlation of hair cortisol and interleukin 6 with structural change in the active progression of keratoconus
| Autor: | Larissa R. Stival, Marcia C. Toledo, Laryssa P Avila, Tiago F Oliveira, Luis Fernando Oliveira Borges Chaves, Marcony R. Santhiago, Daniella C Araujo, Artur C Silva, Luiz C Cunha |
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| Rok vydání: | 2022 |
| Předmět: |
Keratoconus
medicine.medical_specialty Hydrocortisone Cornea Internal medicine medicine Humans Interleukin 8 Interleukin 6 Increased corneal curvature biology Interleukin-6 business.industry Corneal Topography Interleukin medicine.disease Sensory Systems Ophthalmology Interleukin 10 Endocrinology biology.protein Tears Surgery Tumor necrosis factor alpha business Hair |
| Zdroj: | Journal of Cataract and Refractive Surgery. 48:591-598 |
| ISSN: | 1873-4502 0886-3350 |
| DOI: | 10.1097/j.jcrs.0000000000000809 |
| Popis: | PURPOSE Evaluate interleukin and hair cortisol concentrations (HCC) in progressive keratoconus (KC) and compare them with KC stable eyes and healthy controls. Determine the correlation of these inflammatory mediators and HCC and their relationship with structural damage represented by increased corneal curvature. SETTING University of Sao Paulo. DESIGN Prospective observational comparative study. METHODS The study included 135 eyes of 75 patients.The concentrations of tear cytokines: interleukin (IL) 1B, IL6, IL8, IL10, IL12p70 and tumor necrosis factor α (TNFα) were obtained by capillary flow and measured using flow cytometer.HCC were determined from the most proximal hair segment as an index of cumulative secretion and measured by liquid chromatography mass spectrometry. RESULTS Only IL6 was increased in progressive KC tears compared with stable KC (6.59 ± 3.25 pg/ml vs. 4.72 ± 1.91pg/ml; p |
| Databáze: | OpenAIRE |
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